About: Vatalanib Succinate

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Vatalanib Succinate
rdfs:subClassOf	Tyrosine Kinase Inhibitor
Has_Free_Acid_Or_Base_Form	Vatalanib
Has_Target	Vascular Endothelial Growth Factor Receptor-1 Vascular Endothelial Growth Factor Receptor-3 Vascular Endothelial Growth Factor Receptor-2
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Vatalanib Succinate
UMLS_CUI	C1524078
CAS_Registry	212142-18-2
FDA_UNII_Code	V5FUB77031
Contributing_Source	FDA
Chemical_Formula	C20H15ClN4.C4H6O4
Legacy_Concept_Name	Vatalanib_Succinate
FULL_SYN	Butanedioic Acid, Compd. with N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine (1:1)PTDCP50326 PTK787CNNCI PTK 787CNNCI PTK-787CNNCI Vatalanib SuccinatePTNCI ZK 222584CNNCI VATALANIB SUCCINATEPTFDAV5FUB77031 CGP 79787DCNNCI 1-[4-Chloroanilino]-4-[4-pyridylmethyl]phthalazine SuccinateSNNCI
DEFINITION	The succinate salt of vatalanib, an anilinophthalazine derivative, with antineoplastic activity. Vatalanib binds to and inhibits the protein kinase domain of vascular endothelial growth factor receptors 1 and 2; both receptor tyrosine kinases are involved in angiogenesis. This agent also binds to and inhibits related receptor tyrosine kinases, including platelet-derived growth factor (PDGF) receptor, c-Kit, and c-Fms.NCI
code	C74945
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0479626
is Has_Salt_Form of	Vatalanib

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