About: Glycinamide Ribonucleotide Formyltransferase Inhibitor     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Glycinamide Ribonucleotide Formyltransferase Inhibitor
rdfs:subClassOf
Semantic_Type
  • Chemical Viewed Functionally
Preferred_Name
  • Glycinamide Ribonucleotide Formyltransferase Inhibitor
UMLS_CUI
  • C1512220
ALT_DEFINITION
  • A drug that blocks DNA synthesis and may prevent tumor growth. It is being studied as a treatment for cancer.NCI-GLOSS
Legacy_Concept_Name
  • Glycinamide_Ribonucleotide_Formyltransferase_Inhibitor
CHEBI_ID
  • CHEBI:63721
FULL_SYN
  • glycinamide ribonucleotide formyltransferase inhibitorPTNCI-GLOSSCDR0000044824
  • Glycinamide Ribonucleotide Formyltransferase InhibitorPTNCI
DEFINITION
  • Any substance that inhibits glycinamide ribonucleotide formyltransferase, the first folate dependent enzyme in de novo purine synthesis. Inhibition of glycinamide ribonucleotide formyltransferase causes purine depletion and results in inhibition of DNA synthesis and cell cycle arrest.NCI
code
  • C2692
is rdfs:subClassOf of
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