About: Lometrexol Sodium     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Lometrexol Sodium
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Lometrexol Sodium
UMLS_CUI
  • C2983806
CAS_Registry
  • 120408-07-3
FDA_UNII_Code
  • US81N1145T
Contributing_Source
  • FDA
Chemical_Formula
  • C21H23N5O6.2Na
FULL_SYN
  • LY264618 DisodiumCNNCI
  • Lometrexol SodiumPTNCI
  • LOMETREXOL SODIUMPTFDAUS81N1145T
DEFINITION
  • The sodium salt form of lometrexol, a folate analogue antimetabolite with antineoplastic activity. As the stereoisomer of 5,10-dideazatetrahydrofolate, lometrexol selectively inhibits glycinamide ribonucleotide formyltransferase (GARFT), the enzyme that catalyzes the first step in the de novo purine biosynthetic pathway, thereby inhibiting DNA synthesis and leading to an inhibition of tumor cell proliferation. The agent has been shown to be active against tumors that are resistant to the folate antagonist methotrexate, but causes severe, dose-limiting toxicities.NCI
code
  • C90623
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