About: Dideaza-5,6,7,8-Tetrahydrofolic Acid     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Dideaza-5,6,7,8-Tetrahydrofolic Acid
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Dideaza-5,6,7,8-Tetrahydrofolic Acid
UMLS_CUI
  • C1511896
CAS_Registry
  • 95693-76-8
Legacy_Concept_Name
  • Dideaza-5_6_7_8-Tetrahydrofolic_Acid
FULL_SYN
  • Dideaza-5,6,7,8-Tetrahydrofolic AcidSNNCI
  • Dideaza-5,6,7,8-Tetrahydrofolic AcidPTNCI
  • DDATHFABNCI
DEFINITION
  • An antimetabolite and folate analogue with anti-proliferative activity. Dideazatetrahydrofolic acid inhibits activity of glycinamide ribonucleotide formyltransferase (GARFT), the first folate-dependent enzyme of the de novo purine synthesis pathway essential for cell proliferation. Enzyme inhibition reduces the purine nucleotides pool required for DNA replication and RNA transcription. As a result, this agent causes cell cycle arrest in S-phase, and ultimately inhibits tumor cell proliferation.NCI
code
  • C39894
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