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AttributesValues
rdf:type
rdfs:label
  • Lometrexol
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Lometrexol
NSC_Code
  • 660025
UMLS_CUI
  • C0048852
CAS_Registry
  • 106400-81-1
FDA_UNII_Code
  • 6P3AVY8A7Q
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called antifolates.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 41670
PDQ_Closed_Trial_Search_ID
  • 41670
Chemical_Formula
  • C21H25N5O6
Legacy_Concept_Name
  • Lometrexol
FULL_SYN
  • lometrexolPTNCI-GLOSSCDR0000045386
  • Pyrido[2,3-d]pyrimidine, L-glutamic acid derivative (9CI)SNNCI
  • L-Glutamic acid, N-(4-(2-((6R)-2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-d)pyrimidin-6-yl)ethyl)benzoyl)-SNNCI
  • LOMETREXOLPTFDA6P3AVY8A7Q
  • L-Glutamic acid, N-(4-(2-(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-d)pyrimidin-6-yl)ethyl)benzoyl)-, (R)-SNNCI
  • 6R-5,10-DideazatetrahydrofolateSNNCI
  • LometrexolSYDTPNSC0660025
  • LometrexolPTNCI
  • (6R)-DDATHFABNCI
DEFINITION
  • A folate analog antimetabolite with antineoplastic activity. As the 6R diastereomer of 5,10-dideazatetrahydrofolate, lometrexol inhibits glycinamide ribonucleotide formyltransferase (GARFT), the enzyme that catalyzes the first step in the de novo purine biosynthetic pathway, thereby inhibiting DNA synthesis, arresting cells in the S phase of the cell cycle, and inhibiting tumor cell proliferation. The agent has been shown to be active against tumors that are resistant to the folate antagonist methotrexate. (NCI04)NCI
code
  • C979
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