About: Sorafenib Tosylate

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Attributes	Values
rdf:type	Class
rdfs:label	Sorafenib Tosylate
rdfs:subClassOf	Protein Kinase Inhibitor nodeID://b648218 nodeID://b648219 nodeID://b648220 nodeID://b648221 nodeID://b648222
Has_Free_Acid_Or_Base_Form	SORAFENIB
Has_Target	Proto-Oncogene Proteins c-kit Serine/Threonine-Protein Kinase B-Raf RAF-1 Protein Fms-Related Tyrosine Kinase 3 Vascular Endothelial Growth Factor Receptor-3 Vascular Endothelial Growth Factor Receptor-2 Receptor, Platelet-Derived Growth Factor beta
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Sorafenib Tosylate
NSC_Code	724772
UMLS_CUI	C1676709
CAS_Registry	475207-59-1
Accepted_Therapeutic_Use_For	Advanced renal cell carcinoma; Metastatic Colorectal Cancer Major Depressive Disorder
FDA_UNII_Code	5T62Q3B36J
Contributing_Source	FDA
ALT_DEFINITION	A drug used to treat advanced kidney cancer and a type of liver cancer that cannot be removed by surgery. It is also being studied in the treatment of other types of cancer. Nexavar stops cells from dividing and may prevent the growth of new blood vessels that tumors need to grow. It is a type of kinase inhibitor and a type of antiangiogenesis agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID	299013
PDQ_Closed_Trial_Search_ID	299013
Chemical_Formula	C21H16ClF3N4O3.C7H8O3S
Legacy_Concept_Name	BAY_43-9006
CHEBI_ID	CHEBI:50928
FULL_SYN	4-(4-(3-(4-Chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic Acid Methyamide-4-methylbenzenesulfonate TosylateSNNCI sorafenib tosylatePTNCI-GLOSSCDR0000509041 Sorafenib TosylatePTDCP32161 NexavarPTNCI-GLOSSCDR0000470244 Sorafenib TosylatePTNCI NexavarBRNCI SORAFENIB TOSYLATEPTFDA5T62Q3B36J BAY 43-9006 TosylateSYNCI sorafenibPTNCI-GLOSSCDR0000390251 BAY 54-9085CNNCI
DEFINITION	The tosylate salt of sorafenib, a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis.NCI
code	C2194
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0493144
is Has_Salt_Form of	SORAFENIB

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