About: Sorafenib     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Sorafenib
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Sorafenib
UMLS_CUI
  • C1516119
CAS_Registry
  • 284461-73-0
In_Clinical_Trial_For
  • Metastatic, androgen-independent prostate cancer
FDA_UNII_Code
  • 9ZOQ3TZI87
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat advanced kidney cancer and a type of liver cancer that cannot be removed by surgery. It is also being studied in the treatment of other types of cancer. Sorafenib stops cells from dividing and may prevent the growth of new blood vessels that tumors need to grow. It is a type of kinase inhibitor and a type of antiangiogenesis agent.NCI-GLOSS
Chemical_Formula
  • C21H16ClF3N4O3
Legacy_Concept_Name
  • Sorafenib
CHEBI_ID
  • CHEBI:50924
FULL_SYN
  • sorafenibPTNCI-GLOSSCDR0000390251
  • SorafenibPTDCP50517
  • SORAFENIBPTFDA9ZOQ3TZI87
  • SorafenibPTNCI
  • BAY 43-9006CNNCI
  • BAY 43-9006PTNCI-GLOSSCDR0000306493
DEFINITION
  • A synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis.NCI
code
  • C61948
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Free_Acid_Or_Base_Form of
is sameAs of
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 121 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software