About: Topoisomerase-I Inhibitor

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Attributes	Values
rdf:type	Class
rdfs:label	Topoisomerase-I Inhibitor
rdfs:subClassOf	Topoisomerase Inhibitor
Semantic_Type	Chemical Viewed Functionally
Preferred_Name	Topoisomerase-I Inhibitor
UMLS_CUI	C0594374
Legacy_Concept_Name	Topoisomerase-I_Inhibitor
CHEBI_ID	CHEBI:50276
FULL_SYN	Topoisomerase-I InhibitorPTNCI Topoisomerase-I InhibitorsSYNCI
DEFINITION	Any substance that inhibits topoisomerase-I, a topoisomerase that relieves torsional stress in a DNA molecule by cutting only one strand of the DNA double helix. Inhibition of topoisomerase-I causes DNA damage, inhibition of DNA replication, and apoptosis.NCI
code	C1904
is rdf:first of	nodeID://b730279
is rdfs:subClassOf of	Rebeccamycin Pegylated Liposomal Belotecan Pegylated Liposomal Irinotecan SN-38-Loaded Polymeric Micelles NK012 Pegylated Irinotecan Topoisomerase I Inhibitor Genz-644282 Topoisomerase I Inhibitor LMP400 Topoisomerase I Inhibitor LMP776 Lurtotecan Liposome Camptothecin Sodium Aminocamptothecin Colloidal Dispersion Edotecarin Polyglutamate Camptothecin Camptothecin Analogue Camptothecin Bisbenzimidazole Aerosolized Liposomal Rubitecan Cyclodextrin-Based Polymer-Camptothecin CRLX101 Oral Topotecan Hydrochloride Polymeric Camptothecin Prodrug XMT-1001 Polyethyleneglycol-7-ethyl-10-hydroxycamptothecin Topotecan Hydrochloride Liposomes

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