About: Camptothecin Sodium     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Camptothecin Sodium
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Camptothecin Sodium
NSC_Code
  • 100880
UMLS_CUI
  • C1516156
Legacy_Concept_Name
  • Camptothecin_Sodium
FULL_SYN
  • Sodium camptothecinSYDTPNSC0100880
  • Camptothecin sodiumSYDTPNSC0100880
  • Camptothecin Sodium SaltSYNCI
  • Camptothecin SodiumPTNCI
  • Camptothecin, sodium saltSYDTPNSC0100880
DEFINITION
  • The sodium salt of camptothecin, an alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. The sodium salt of camptothecin is more water-soluble than the parent molecule. (NCI04)NCI
code
  • C2344
is Has_Salt_Form of
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