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AttributesValues
rdf:type
rdfs:label
  • Camptothecin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Camptothecin
NSC_Code
  • 94600
UMLS_CUI
  • C0006812
CAS_Registry
  • 7689-03-4
FDA_UNII_Code
  • XT3Z54Z28A
Contributing_Source
  • FDA
ALT_DEFINITION
  • An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 39173
PDQ_Closed_Trial_Search_ID
  • 39173
Chemical_Formula
  • C20H16N2O4
Legacy_Concept_Name
  • Camptothecin
CHEBI_ID
  • CHEBI:27656
FULL_SYN
  • CAMPTOTHECINPTFDAXT3Z54Z28A
  • (S)-4-ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolozino[1,2-b]quinoline-3,14(4H,12H)-dioneSNNCI
  • 21, 22-secocamptothecin-21-oic acid lactoneSNNCI
  • CamptothecinPTNCI
  • camptothecineSYNCI
  • 21, 22-Secocamptothecin-21-oic acid lactoneSYDTPNSC0094600
  • camptothecinPTNCI-GLOSSCDR0000045181
  • (+)-CamptothecinSYNCI
  • 1H-Pyrano[3',3'.6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4hydroxy-(S)-(9CI)SNNCI
  • 20-(S)-camptothecineSYNCI
  • (+)-CamptothecinPTDCP09054
  • 20(S)-CamptothecineSYDTPNSC0094600
DEFINITION
  • An alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. (NCI)NCI
code
  • C338
sameAs
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