About: Rebeccamycin

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Rebeccamycin
rdfs:subClassOf	Topoisomerase-I Inhibitor DNA Intercalating Agent
Semantic_Type	Antibiotic Organic Chemical
Preferred_Name	Rebeccamycin
NSC_Code	359079
UMLS_CUI	C0073012
CAS_Registry	93908-02-2
ALT_DEFINITION	A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antineoplastic antibiotics.NCI-GLOSS
Legacy_Concept_Name	Rebeccamycin
CHEBI_ID	CHEBI:135511
FULL_SYN	RebeccamycinSYDTPNSC0359079 5H-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione,1,11-dichloro-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl)SNNCI RebeccamycinPTNCI rebeccamycinPTNCI-GLOSSCDR0000045860 5H-Indolo[2, 3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 1,11-dichloro-12, 13-dihydro-12-(4-O-methyl-.beta.-D-glucopyranosyl)-SYDTPNSC0359079 BRN 4732638CNNCI
DEFINITION	An indolocarbazole glycoside antineoplastic antibiotic isolated from the bacterium Saccharothrix aerocolonigenes. Rebeccamycin intercalates into DNA and stabilizes the DNA-topoisomerase I complex, thereby interfering with the topoisomerase I-catalyzed DNA breakage-reunion reaction and initiating DNA cleavage and apoptosis. (NCI04)NCI
code	C1213
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0151075

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