About: Anthracycline Antineoplastic Antibiotic

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About: Anthracycline Antineoplastic Antibiotic Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Anthracycline Antineoplastic Antibiotic
rdfs:subClassOf	Topoisomerase-II Inhibitor DNA Minor Groove Binding Agent ANTINEOPLASTIC ANTIBIOTICS
Semantic_Type	Chemical Viewed Functionally
Preferred_Name	Anthracycline Antineoplastic Antibiotic
UMLS_CUI	C0282564
ALT_DEFINITION	A type of antibiotic that comes from certain types of Streptomyces bacteria. Anthracyclines are used to treat many types of cancer. Anthracyclines damage the DNA in cancer cells, causing them to die. Daunorubicin, doxorubicin, and epirubicin are anthracyclines.NCI-GLOSS
Legacy_Concept_Name	Anthracycline_Antibiotic
CHEBI_ID	CHEBI:49322
FULL_SYN	AnthracyclinesSYNCI Chemotherapy, Cancer, AnthracyclinesSYNCI anthracyclinePTNCI-GLOSSCDR0000044916 Anthracycline Antineoplastic AntibioticPTNCI
DEFINITION	An antineoplastic antibiotic that is structurally similar to the benzoquinone ansamycin antibiotic geldanamycin. A geldanamycin analogue binds to HSP90, a chaperone protein that aids in the assembly, maturation, and folding of proteins. Subsequently, the function of HSP90 is inhibited, leading to the degradation and depletion of client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.NCI
code	C1594
sameAs	Anthracyclines
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0028312
is rdf:first of	nodeID://b729745 nodeID://b729746
is rdfs:subClassOf of	Marcellomycin VALRUBICIN Morpholinodoxorubicin 7-Cyanoquinocarcinol Sabarubicin L-377,202 N,N-Dibenzyl Daunomycin Liposomal Cytarabine-Daunorubicin CPX-351 Nogalamycin Leurubicin Ladirubicin Nemorubicin Hydrochloride Medorubicin Zorubicin Rodorubicin Duborimycin Detorubicin Pirarubicin Menogaril Zorubicin Hydrochloride Carubicin Hydrochloride Daunorubicin Hydrochloride Idarubicin Hydrochloride Liposomal Daunorubicin Citrate 13-Deoxydoxorubicin Annamycin Carubicin Epirubicin Hydrochloride Daunorubicin Citrate Amrubicin Hydrochloride IDARUBICIN Berubicin Hydrochloride EPIRUBICIN DAUNORUBICIN Doxorubicin Preparation Esorubicin Hydrochloride Anthracycline Analogue GPX-150 Amrubicin Galarubicin Doxorubicin-Eluting Beads Berubicin Nemorubicin Idarubicin-Eluting Beads Pirarubicin Hydrochloride Esorubicin Aclacinomycin Antitumor Antibiotic
is sameAs of	Anthracyclines

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