About: Idarubicin

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Idarubicin
rdfs:subClassOf	Anthracyclines
Has_Salt_Form	Idarubicin Hydrochloride
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Antibiotic Organic Chemical
Preferred_Name	Idarubicin
UMLS_CUI	C0020789
CAS_Registry	58957-92-9
Accepted_Therapeutic_Use_For	Acute myeloid leukemia; acute nonlymphocytic leukemia
FDA_UNII_Code	ZRP63D75JW
Contributing_Source	FDA
ALT_DEFINITION	An anticancer drug that belongs to the family of drugs called antitumor antibiotics.NCI-GLOSS
PDQ_Open_Trial_Search_ID	39753
PDQ_Closed_Trial_Search_ID	39753
Chemical_Formula	C26H27NO9
Legacy_Concept_Name	Idarubicin
CHEBI_ID	CHEBI:42068
FULL_SYN	idarubicinPTNCI-GLOSSCDR0000045254 4-DemethoxydaunorubicinSYNCI (1S,3S)-3-Acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-trideoxy-alpha-L-hexopyranosideSNNCI 4-DMDRABNCI IDARUBICINPTFDAZRP63D75JW (7S-cis)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedioneSNNCI 4-DemethoxydaunomycinSYNCI 4-demethoxydaunorubicinPTNCI-GLOSSCDR0000044413 IdarubicinPTNCI
DEFINITION	A semisynthetic 4-demethoxy analogue of the antineoplastic anthracycline antibiotic daunorubicin. Idarubicin intercalates into DNA and interferes with the activity of topoisomerase II, thereby inhibiting DNA replication, RNA transcription and protein synthesis. Due to its high lipophilicity, idarubicin penetrates cell membranes more efficiently than other anthracycline antibiotic compounds.NCI
code	C562
sameAs	IDARUBICIN
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0023493
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is Has_Free_Acid_Or_Base_Form of	Idarubicin Hydrochloride
is sameAs of	IDARUBICIN IDARUBICIN

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