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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Valrubicin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Organic Chemical
Preferred_Name
  • Valrubicin
NSC_Code
  • 246131
UMLS_CUI
  • C0068314
CAS_Registry
  • 56124-62-0
FDA_UNII_Code
  • 2C6NUM6878
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat bladder cancer that does not respond to BCG (Bacillus Calmette Guerin). It is an anthracycline and is a type of antitumor antibiotic.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 39135
PDQ_Closed_Trial_Search_ID
  • 39135
Chemical_Formula
  • C34H36F3NO13
Legacy_Concept_Name
  • Valrubicin
FULL_SYN
  • N-Trifluoroacetyladriamycin-14-valerateSYDTPNSC0246131
  • AD 32SYDTPNSC0246131
  • valrubicinPTNCI-GLOSSCDR0000390320
  • AD 32PTNCI-GLOSSCDR0000045168
  • AD 32CNNCI
  • AD-32CNNCI
  • N-Trifluoroacetyladriamycin-14-valerateSNNCI
  • ValstarBRNCI
  • VALRUBICINPTFDA2C6NUM6878
  • ValtaxinFBNCI
  • ValrubicinPTNCI
DEFINITION
  • A semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin. With a mechanism of action that appears to differ from doxorubicin, valrubicin is converted intracytoplasmically into N-trifluoroacetyladriamycin, which interacts with topoisomerase II, stabilizing the complex between the enzyme and DNA; consequently, DNA replication and repair and RNA and protein synthesis are inhibited and the cell cycle is arrested in the G2 phase. In addition, this agent accumulates in the cell cytoplasm where it inhibits protein kinase C (PKC). Valrubicin is less cardiotoxic than doxorubicin when administered systemically; applied topically, this agent shows excellent tissue penetration. Structurally, the trifluoro-acetyl moiety on the amino group of the glycoside and the valerate moiety appear to result in a lipophilicity that is greater than of doxorubicin, resulting in increased intracytoplasmic concentrations.NCI
code
  • C1340
sameAs
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