About: Liposomal Cytarabine-Daunorubicin CPX-351     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Liposomal Cytarabine-Daunorubicin CPX-351
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Liposomal Cytarabine-Daunorubicin CPX-351
NCI_META_CUI
  • CL372099
PDQ_Open_Trial_Search_ID
  • 554979
PDQ_Closed_Trial_Search_ID
  • 554979
Legacy_Concept_Name
  • Liposomal_Cytarabine-Daunorubicin_CPX-351
FULL_SYN
  • Liposomal AraC-Daunorubicin CPX-351SYNCI
  • Cytarabine-Daunorubicin Liposome for InjectionSYNCI
  • CPX-351SYNCI
  • Liposomal Cytarabine-Daunorubicin CPX-351PTNCI
DEFINITION
  • A liposomal formulation containing a fixed combination of the antineoplastic agents cytarabine and daunorubicin in a 5:1 molar ratio. Liposomal cytarabine-daunorubicin CPX-351 has been designed to provide optimal delivery of a specific ratio of cytarabine to daunorubicin, one that has been shown to be synergistic in vitro. The antimetabolite cytarabine competes with cytidine for incorporation into DNA, inhibiting DNA synthesis. This agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. Daunorubicin, an intercalator and a topoisomerase II inhibitor, prevents DNA replication and inhibits protein synthesis. This agent also generates oxygen free radicals, resulting in the cytotoxic lipid peroxidation of cell membrane lipids.NCI
code
  • C67504
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