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| Description
| - The function and regulation of enzymes will be studied by novel methods suitable for monitoring of in vivo activity via monitoring of intracellular metabolites. We will continue to use structural methods.Keywords of the long-term research plan are protein, its function, structure, structure-function relationships and complexes of proteins. More general keywords are proteome and metabolome. The project will focus on such hot topicsof current life sciences like protein/DNA interactions, synthesis of proteins on ribosome or applications of photo-labile groups for directed geometrical changes of protein-substrate complexes and regulation of enzymatic reactions. (en)
- Návrh bezprostředně navazuje na předchozí výzkumný záměr %22Strukturně funkční vztahy biomolekul a jejich role v metabolismu%22, řešený v letech 1998-2004, a zčásti i na projekt %22Laboratoř struktury a dynamiky biomolekul%22 v rámci programu %22250%22 (1996-2000).záměru byla identifikace a charakterizace vybraných bakteriálních proteinů a nízkomolekulárních látek účastnících se metabolismu bakterií a hub. Nově navrhovaný záměr by měl jednak zahrnout i další proteiny z jiných typů organismů, např. živočišné protepřínosem bude rozšíření předmětu zájmu na interakce proteinů s okolím. Řečeno jinak, hlavní inovací bude to, že předmětem zájmu budou komplexy proteinů. Při studiu funkce a regulace enzymů se zaměříme i na rozvoj metod monitorování jejich aktivity za pometabolitů. Zapojení odborníků z oblasti instrumentální analytické chemie a experimentální organické chemie a fotochemie umožní neomezovat se na, z pohledu řady metod, „uživatelský přístup“, ale vyvíjet vlastní aktivity k dalšímu rozvoji a implementaci t
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| Title
| - Proteiny v metabolismu a při interakci organismů s prostředím
- Proteins in metabolism and interaction of organisms with the environment (en)
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ez/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...vavai/cez/dodavka
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| http://linked.open...ez/duvernostUdaju
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| http://linked.open...in/vavai/cez/faze
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| http://linked.open...ai/cez/hlavniObor
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| http://linked.open...vai/cez/hodnoceni
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| http://linked.open.../cez/kategorieVaV
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| http://linked.open.../cez/klicovaSlova
| - Proteins; metabolism (en)
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| http://linked.open...cez/partnerHlavni
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| http://linked.open...z/poceVysledkuRIV
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cez/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open.../vavai/cez/resort
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ez/ukonceniReseni
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| http://linked.open.../cez/vedlejsiObor
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| http://linked.open...ez/zahajeniReseni
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| http://linked.open...n/vavai/cez/zamer
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| http://linked.open...sledkuDodavatelem
| - Komplexní přístup ke studiu proteinů zahrnuje jejich identifikaci v genomu, izolaci z přírodních zdrojů či přípravu proteinů rekombinantních, zjišťování vztahů mezi strukturou, mechanismem působení a biologickou funkcí a rozpracování případných aplikačních možností. A právě takový komplexní mezioborový výzkum byl předmětem tohoto výzkumného záměru. (cs)
- The comprehensive approach to the studies of proteins includes their identification in the genome, isolation from the natural sources or preparation of the recombinant proteins, elucidation of the relationships between the structure, mechanism and biological function and elaboration of possible applications. This highly interdisciplinary research was the subject of this research project. (en)
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| http://linked.open...cez/zivotniCyklus
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| is http://linked.open...n/vavai/riv/zamer
of | - Effect of theTemperature on the Structure and Function Haloalkan Dehalogenas DbjA.
- The Mechanism of Inhibition of the Cyclin-Dependent Kinase-2 as Revealed by the Molecular Dynamics Study on the Complex CDK2 with the Peptide Substrate HHASPRK
- The study on the FnrP, NNR and NarR transcription regulator function in bacterium Paracoccus denitrificans at global proteome level
- <SUP>13</SUP>C CHEMICAL SHIFT TENSORS IN REGIOISOMERS OF <I>N</I>-SUBSTITUTED ADENINES
- Protein Modification Degree - An Indirect MS Quantitation Approach.
- Rational Engineering of Haloalkane Dehalogenases
- Využití MALDI-MS pro identifikaci Pseudomonas spp.
- UPS AND DOWNS OF HOMOLOGOUS RECOMBINATION
- Theoretical Description of Carbohydrate-Aromatic CH-pi Interactions Additive Properties via DFT and Ab Initio Calculations
- Type I iodothyronine 5-deiodinase mRNA and activity is increased in adipose tissue of obese subjects
- Geometrical and electronic structure variability of the sugar-phosphate backbone in nucleic acids
- General Base Catalysis for Cleavage by the Active-Site Cytosine of the Hepatitis Delta Virus Ribozyme: QM/MM Calculations Establish Chemical Feasibility
- Understanding the NMR chemical shifts for 6-halopurines: role of structure, solvent and relativistic effects
- Interpretation of Indirect Nuclear Spin-Spin Couplings in Isomers of Adenine: Novel Approach to Analyze Coupling Electron Deformation Density Using Localized Molecular Orbitals
- Cytotoxic Activities of Several Geranyl-Substituted Flavanones
- H-1-, C-13-, and N-15-NMR chemical shifts for selected glucosides and ribosides of aromatic cytokinins
- Cdk1 targets Srs2 to complete synthesis-dependent strand annealing and to promote
- Extractions of isoquinoline alkaloids with butanol and octanol
- Single stranded loops of quadruplex DNA as key benchmark for testing nucleic acids force fields
- Dependence of A-RNA simulations on the choice of the force field and salt strength
- On the role of the cis Hoogsteen:sugar-edge family of base pairs in platforms and triplets-quantum chemical insights into RNA structural biology
- Structural dynamics of the box C/D RNA Kink-Turn and its complex with proteins: The role of the A-minor 0 interaction, long-residency water bridges, and structural ion-binding sites revealed by molecular simulations
- Molecular dynamics simulations suggest that RNA three-way junctions can act as flexible RNA structural elements in the ribosome
- Reference MP2/CBS and CCSD(T) quantum-chemical calculations on stacked adenine dimers. Comparison with DFT-D, MP2.5, SCS(MI)-MP2, M06-2X, CBS(SCS-D) and force field descriptions
- Aspergillus fumigatus lectin – a new procedure for studying highly complex interactions of multivalent lectins with their ligands
- ANALYTICAL ULTRACENTRIFUGATION AS AN EFFECTIVE TOOL FOR IDENTIFICATION OF PROTEIN OLIGOMERIC STATE
- Anion Binding by Bambus[6]uril Probed in the Gas Phase and in Solution
- Bambus[n]urils: a new family of macrocyclic anion receptors
- Anion-free bambus[6]uril and its supramolecular properties
- Engineering Robust and Efficient Protein Catalysts
- Elicitine-membrane interaction is driven by a positive charge on the protein surface: Role of Lys13 residue in lipids loading and resistance induction
- Expression of problematic glycosyltransferase Rv3782 from Mycobacterium tuberculosis
- Expression of glycosyltransferase in fussion with MBP and following TEV protease cleavage
- Fe/Mn superoxide dismutase in Paracoccus denitrificans is induced by azide and expressed independently on FNR-type regulators
- Function and structure studies of lectin from bioluminescent bacterium Photorhabdus luminescens
- Glycosyltransferase Rv3782 from Mycobacterium tuberculosis and its expression in new vector pMTW
- The Five Bacterial Lectins: PA-IL, PA-IIL, RSL, RS-IIL and CV-IIL Interactions with Diverse Animal Cells and Glycoproteins.
- Fucose-binding lectin from human pathogen Aspergillus fumigatus
- In vitro protein and metabolic engineering of a biodegradation pathway
- Influence of Zinc(II) and Copper(II) Ions on Streptomyces Bacteria Revealed by Electrochemistry
- Interpretation of substituent effects on 13C and 15N NMR chemical shifts in 6-substituted purines
- Kvantové tečky: příprava, konjugace a využití v bioanalytické chemii a biologii
- Kvantifikace proteinových biomarkerů pomocí hmotnostní spektrometrie pracující v režimu monitorování vybraných reakcí
- Molecular bases of enantioselectivity of haloalkane dehalogenase DbjA.
- Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro
- Predicting pK(a) values of substituted phenols from atomic charges: Comparison of different quantum mechanical methods and charge distribution schemes
- The Power of Solvent in Altering the Course of Photorearrangements
- Selectivity among Two Lectins: Probing the Effect of Topology, Multivalency and Flexibility of “Clicked” Multivalent Glycoclusters
- Structure and function of lectins from Burkholderia cenocepacia - similar, yet different
- Study of ergosterol signal pathway
- Structural analysis of delta-subnit of RNA-polymerase by X-ray
- Structure and specificity of a blood group oligosaccharide specific lectin from Aspergillus fumigatus
- STUDY OF THE CARBOHYDRATE CH/pi INTERACTIONS FAVOURABLE REGIONS IN THE CARBOHYDRATE SURROUNDINGS
- Structure and binding specificity of the receiver domain of sensor histidine kinase CKI1 from Arabidopsis thaliana.
- Unprecedented .pi. ... .pi. interaction between an aromatic ring and a pseudo-aromatic ring formed through intramolecular H-bonding in a bidentate Schiff base ligand: crystal structure and DFT calculations
- The X-ray structure versus NMR structure of delta-subunit of RNA-polymerase
- Biotinylation of quantum dots for application in fluoroimmunoassays with biotin-avidin amplification
- FastGrid -- The Accelerated Computation of Potential Maps for Molecular Docking
- Decontamination of chemical warfare agent sulphur mustard
- MOLE 1.n
- MOLEOnline 1.n
- TRITON 4 : software for ligand-binding protein engineering
- Neurobiologie hyperkinetické poruchy
- Partially O-Alkylated thiacalix[4]arenes: Synthesis, molecular and crystal structures, conformational behavior
- Purification and some properties of thiosulfate dehydrogenase from Acidithiobacillus ferrooxidans
- Quaternary protoberberine alkaloids
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