About: Effect of zearalenone on reproductive parameters and expression of selected testicular genes in mice

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We tested the effect of two different concentrations (150μg/l and 0.15μg/l) of mycotoxin zearalenone (ZEA) on the reproductive parameters and expression of testicular genes in male mice. In adult males, no reduction of body or reproductive organ weight was observed, and the seminiferous tubules were morphologically normal with ongoing spermatogenesis. However, we found decreased sperm concentration, increase of morphologically abnormal spermatozoa and increased binding of apoptotic marker annexin V. This study was also focused on the evaluation of gene expression profiles of 28 genes playing important roles during the processes occurring in the testicular tissue. We detected changes in the expression of genes important for proper spermatogenesis. Surprisingly, we observed a stronger effect after exposure to the lower dose of ZEA. We tested the effect of two different concentrations (150μg/l and 0.15μg/l) of mycotoxin zearalenone (ZEA) on the reproductive parameters and expression of testicular genes in male mice. In adult males, no reduction of body or reproductive organ weight was observed, and the seminiferous tubules were morphologically normal with ongoing spermatogenesis. However, we found decreased sperm concentration, increase of morphologically abnormal spermatozoa and increased binding of apoptotic marker annexin V. This study was also focused on the evaluation of gene expression profiles of 28 genes playing important roles during the processes occurring in the testicular tissue. We detected changes in the expression of genes important for proper spermatogenesis. Surprisingly, we observed a stronger effect after exposure to the lower dose of ZEA. (en)
Title	Effect of zearalenone on reproductive parameters and expression of selected testicular genes in mice Effect of zearalenone on reproductive parameters and expression of selected testicular genes in mice (en)
skos:prefLabel	Effect of zearalenone on reproductive parameters and expression of selected testicular genes in mice Effect of zearalenone on reproductive parameters and expression of selected testicular genes in mice (en)
skos:notation	RIV/86652036:_____/14:00434230!RIV15-GA0-86652036
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0109), P(GAP503/12/1834), S, Z(AV0Z50520701)
http://linked.open...iv/cisloPeriodika	june
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Pěknicová, Jana Elzeinová, Fatima Dostálová, Pavla Žatecká, Eva Korenková, Vlasta Kubátová, Alena Děd, Lukáš Dorosh, Andriy Margaryan, Hasmik
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biotechnologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	13607
http://linked.open...ai/riv/idVysledku	RIV/86652036:_____/14:00434230
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	zearalenone; fertility; reproductive parameters in male mice; spermatogenesis; gene expression; qPCR (en)
http://linked.open.../riv/klicoveSlovo	reproductive parameters in male mice gene expression zearalenone qPCR spermatogenesis fertility
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[5C7AEC2BB578]
http://linked.open...i/riv/nazevZdroje	Reproductive Toxicology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University Identification of epigenetic biomarkers of male germ cell disorders linked to adverse environmental factors
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	45
http://linked.open...iv/tvurceVysledku	Elzeinová, Fatima Pěknicová, Jana Žatecká, Eva Kubátová, Alena Korenková, Vlasta Dorosh, Andriy Děd, Lukáš Margaryan, Hasmik Dostálová, Pavla Hošková, K.
http://linked.open...ain/vavai/riv/wos	000336415800004
http://linked.open...n/vavai/riv/zamer	Establishing of the Biotechnology Institute ASCR
issn	0890-6238
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.reprotox.2014.01.003

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