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| Description
| - The mechanism by which some environmental substances called endocrine disruptors (Eds) affect the reproduction of living organisms is still unknown. In this project we will identify the epigenetic changes in reproductive organs after exposure to EDs in vivo and in vitro in the mouse (inbred, outbred) and fish model. Mice and fish will be exposed during embryonic development to EDs at different doses and the transfer of epigenetic defects in the gonads and germ cells in future generations will be monitored. The analysis will focus on changes in DNA methylation and histone posttranslational modification. Analysis of changes in the level of molecules and cells will be carried out on spermatozoa and spermatogonial stem cells. At the level of phenotype changes will be assessed by histopathology of male gonads and sperm analysis. The aim of this project will be to identify and validate biomarkers that mediate inter-generational transfer of male gonadal dysfunction as a result of exposure to selected contaminants in both species. (en)
- Stále ještě není známé, jakým mechanismem některé látky životního prostředí tzv. endokrinní disruptory (EDs) ovlivňují reprodukci živých organismů. V tomto projektu budeme na savčím modelu, myši (inbrední, outbrední) a rybím modelu zjišťovat epigenetické změny v reprodukčních orgánech po vystavení EDs v podmínkách in vivo. Myši a ryby budou vystaveny během embryonálního vývoje působení EDs v různých dávkách a bude sledován přenos epigenetických poruch v gonádách a zárodečných buňkách v dalších generacích. Analýza bude zaměřena na změny DNA methylace and histonové posttranslační modifikace. Analýza změn na úrovni molekul a buněk bude prováděna na spermiích, spermatogoniích a zárodečných buňkách. Na úrovni fenotypu bude hodnocena histopatologie samčích gonád a funkční analýza spermií. Cílem tohoto projektu bude zjistit a ověřit biomarkery, které zprostředkovávají mezigenerační přenos samčí gonadální dysfunkce jako důsledek expozice vybraných polutantů u obou druhů živočichů.
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| Title
| - Identification of epigenetic biomarkers of male germ cell disorders linked to adverse environmental factors (en)
- Identifikace epigenetických biomarkerů samčích zárodečných buněk poškozených nepříznivými vlivy životního prostředí
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - Endocrine disruptors DNA-methylation histone post-transcriptional modifications microRNA expression Primordial Germ Cells spermatids spermatozoa histopathology (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...ep/ukonceniReseni
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...ep/zahajeniReseni
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| http://linked.open...tniCyklusProjektu
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| is http://linked.open...vavai/riv/projekt
of | - The effect of tetrabromobisphenol A on protamine content and DNA integrity in mouse spermatozoa
- Effect of zearalenone on reproductive parameters and expression of selected testicular genes in mice
- Physiological functions of osmolality and calcium ions on the initiation of sperm motility and swimming performance in redside dace, Clinostomus elongatus
- Adverse effect of tetracycline and doxycycline on reproductive tract development of CD1 mice
- Adverse effect of tetracycline and doxycycline on testicular tissue and sperm parameters in CD1 outbred mice
- Characterization of sperm surface protein patterns of ejaculated and capacitated boar sperm, with the detection of ZP binding candidates
- Expression analysis of MND1/GAJ, SPATA22, GAPDHS and ACR genes in testicular biopsies from non-obstructive azoospermia (NOA) patients
- In vivo exposure to 17 beta-estradiol triggers premature sperm capacitation in cauda epididymis
- The role of ubiquitin–proteasome pathway in the regulation of activity of two sperm surface proteins the aqn1 spermadhesin And the acrosin inhibitor in boar fertilization
- Sperm morphology, motility, and velocity in naturally occurring polyploid European weatherfish (Misgurnus fossilis L.)
- Toxicity of environmental contaminants to fish spermatozoa function in vitro-A review
- Characterization of human sperm protein recognized by monoclonal antibody HS-8
- Modulations in androgen and estrogen mediating genes and testicular response in male goldfish exposed to bisphenol A
- Sperm morphology and biology in sturgeon
- Sperm biology and control of reproduction in sturgeon: (II) sperm morphology, acrosome reaction, motility and cryopreservation
- Sperm characteristics and androgens in Acipenser ruthenus after induction of spermiation by carp pituitary extract or GnRHa implants
- Sperm surface protein AQ1 spermadhesin and ubiquitin-proteasome pathway in porcine anti-polyspermy defense
- Progress of sperm IZUMO1 relocation during spontaneous acrosome reaction
- Protease in sturgeon sperm and the effects of protease inhibitors on sperm motility and velocity
- Protease in sturgeon sperm and the effect of protease inhibitors on sperm motility and velocity
- Alternations in neuroendocrine and endocrine regulation of reproduction in male goldfish (Carassius auratus) following an acute and chronic exposure to vinclozolin, in vivo
- Sperm morphology, ultrastructure, and motility in pikeperch Sander lucioperca (Percidae, Teleostei) associated with various activation media
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| is http://linked.open...vavai/cep/projekt
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