About: Adverse effect of tetracycline and doxycycline on testicular tissue and sperm parameters in CD1 outbred mice

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About: Adverse effect of tetracycline and doxycycline on testicular tissue and sperm parameters in CD1 outbred mice Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Tetracycline and doxycycline are commonly used antibiotics in acne treatment during puberty in humans. The long-term effect of these antibiotics on male reproductive tract development has not been fully elucidated. For this reason we tested the effect of antibiotics on the reproductive parameters of mice males during puberty with the therapeutic dose used in humans, and with lower and higher doses. The outbred mouse strain CD1 with higher heterozygosity was exposed for 14 days at puberty. Adult males at the age of 70 days were used for the measurements. We observed a significant decrease in anogenital distance and thickness of the seminiferous epithelium in the treated animals. Pathological changes in the testes had an impact on sperm quality; a higher number of sperm positively stained with Annexin V and TUNEL and a lower number of acrosome-intact sperm was detected. In conclusion, the treatment of male mice with antibiotics in puberty led to long-lasting effects on reproductive organs and spermatoz Tetracycline and doxycycline are commonly used antibiotics in acne treatment during puberty in humans. The long-term effect of these antibiotics on male reproductive tract development has not been fully elucidated. For this reason we tested the effect of antibiotics on the reproductive parameters of mice males during puberty with the therapeutic dose used in humans, and with lower and higher doses. The outbred mouse strain CD1 with higher heterozygosity was exposed for 14 days at puberty. Adult males at the age of 70 days were used for the measurements. We observed a significant decrease in anogenital distance and thickness of the seminiferous epithelium in the treated animals. Pathological changes in the testes had an impact on sperm quality; a higher number of sperm positively stained with Annexin V and TUNEL and a lower number of acrosome-intact sperm was detected. In conclusion, the treatment of male mice with antibiotics in puberty led to long-lasting effects on reproductive organs and spermatoz (en)
Title	Adverse effect of tetracycline and doxycycline on testicular tissue and sperm parameters in CD1 outbred mice Adverse effect of tetracycline and doxycycline on testicular tissue and sperm parameters in CD1 outbred mice (en)
skos:prefLabel	Adverse effect of tetracycline and doxycycline on testicular tissue and sperm parameters in CD1 outbred mice Adverse effect of tetracycline and doxycycline on testicular tissue and sperm parameters in CD1 outbred mice (en)
skos:notation	RIV/60460709:41210/13:60405!RIV14-MSM-41210___
http://linked.open...avai/predkladatel	Fakulta agrobiologie, potravinových a přírodních zdrojů
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(1M06011), P(GA523/09/1793), P(GAP503/12/1834), S, Z(AV0Z50520701)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Rajmon, Radko Makovický, Peter
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Česká zemědělská univerzita v Praze / Fakulta agrobiologie, potravinových a přírodních zdrojů
http://linked.open...dnocenehoVysledku	59664
http://linked.open...ai/riv/idVysledku	RIV/60460709:41210/13:60405
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Tetracycline, Doxycycline, Testes, Sperm, Apoptosis, Puberty (en)
http://linked.open.../riv/klicoveSlovo	Doxycycline Testes Tetracycline Apoptosis Puberty Sperm
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[032703AAE781]
http://linked.open...i/riv/nazevZdroje	EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
http://linked.open...in/vavai/riv/obor	EA
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Effect of endocrine disruptors on reproductive parameters and expression of selected genes in mouse gonads. Identification of epigenetic biomarkers of male germ cell disorders linked to adverse environmental factors The Centre of Molecular Methods for Monitoring the Diffuse Pollution of the Environment.
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	65
http://linked.open...iv/tvurceVysledku	Elzeinová, Fatima Pěknicová, Jana Rajmon, Radko Makovický, Peter Kubátová, Alena Dorosh, Andriy Děd, Lukáš Margaryan, Hasmik
http://linked.open...ain/vavai/riv/wos	000322929800024
http://linked.open...n/vavai/riv/zamer	Establishing of the Biotechnology Institute ASCR
issn	0940-2993
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	41210

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