About: Commensal intestinal bacterial strains trigger ankylosing enthesopathy of the ankle in inbred B10.BR (H-2k) male mice     Goto   Sponge   NotDistinct   Permalink

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  • Joint disease ankylosing enthesopathy (ANKENT) naturally occurs in inbred mice with C57Bl/10 background. ANKENT has many parallels to human ankylosing spondylitis (AS) and represents an animal model for AS. Microbial load of the organism is among the risk factors for ANKENT, similar to AS. The role of microflora in ANKENT development was investigated. ANKENT was tested in germ-free (GF) mice associated with different intestinal microbes and in control germ-free, SPF, and conventional (CV) mice. Joint disease developed in GF mice colonized with a mixture containing Bacteroides spp. and Enterococcus sp., and/or Veillonella sp. and Staphylococcus sp. No ANKENT appeared after colonization with probiotic Lactobacillus sp. and in GF mice. The results confirmed that the germ-free conditions protect from joint inflammation. In colonized mice the ANKENT was triggered by common luminal anaerobic bacteria
  • Joint disease ankylosing enthesopathy (ANKENT) naturally occurs in inbred mice with C57Bl/10 background. ANKENT has many parallels to human ankylosing spondylitis (AS) and represents an animal model for AS. Microbial load of the organism is among the risk factors for ANKENT, similar to AS. The role of microflora in ANKENT development was investigated. ANKENT was tested in germ-free (GF) mice associated with different intestinal microbes and in control germ-free, SPF, and conventional (CV) mice. Joint disease developed in GF mice colonized with a mixture containing Bacteroides spp. and Enterococcus sp., and/or Veillonella sp. and Staphylococcus sp. No ANKENT appeared after colonization with probiotic Lactobacillus sp. and in GF mice. The results confirmed that the germ-free conditions protect from joint inflammation. In colonized mice the ANKENT was triggered by common luminal anaerobic bacteria (en)
  • U inbredních myších kmenů s C57Bl/10 pozadím se vyskytuje kloubní onemocnění ankylosující enthesopatie (ANKENT). ANKENT má četné paralely s lidským onemocněním ankylosující spondylitidou (AS). Mezi rizikové faktory pro ANKENT a také pro AS patří mikrobiální osazení organismu. Proto byla zkoumána úloha mikroflory při vzniku onemocnění. Výskyt ANKENT byl sledován u germ-free (GF) myší asociovaných s různými střevními bakteriemi a u kontrolních GF, SPF a konvečních myší. Kloubní onemocnění se vyskytlo u GF myší kolonizovaných Bacteroides spp. and Enterococcus sp., nebo Veillonella sp. a Staphylococcus sp. Žádný ANKENT nebyl pozorován po kolonizaci probiotickou bakterií Lactobacillus sp a u GF myší. Výsledky ukázaly, že bezmikrobní podmínky chrání před vznikem onemocnění. U kolonizovaných myší byl ANKENT spouštěn běžnými luminálními anaerobními bakteriemi. (cs)
Title
  • Commensal intestinal bacterial strains trigger ankylosing enthesopathy of the ankle in inbred B10.BR (H-2k) male mice
  • Běžné střevní bakteriální kmeny spouští ankylosující enthesopthii kotníku u samců myšího inbredního kmene Bl0.BR (H-2k) (cs)
  • Commensal intestinal bacterial strains trigger ankylosing enthesopathy of the ankle in inbred B10.BR (H-2k) male mice (en)
skos:prefLabel
  • Commensal intestinal bacterial strains trigger ankylosing enthesopathy of the ankle in inbred B10.BR (H-2k) male mice
  • Běžné střevní bakteriální kmeny spouští ankylosující enthesopthii kotníku u samců myšího inbredního kmene Bl0.BR (H-2k) (cs)
  • Commensal intestinal bacterial strains trigger ankylosing enthesopathy of the ankle in inbred B10.BR (H-2k) male mice (en)
skos:notation
  • RIV/86652036:_____/08:00322992!RIV09-AV0-86652036
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(2B08028), P(GA305/03/0287), Z(AV0Z5020903), Z(AV0Z50520701)
http://linked.open...iv/cisloPeriodika
  • 12
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 360438
http://linked.open...ai/riv/idVysledku
  • RIV/86652036:_____/08:00322992
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Spondyloarthropathies; Ankylosing enthesopathy; Intestinal microflora (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [DCD091159C50]
http://linked.open...i/riv/nazevZdroje
  • Human Immunology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 69
http://linked.open...iv/tvurceVysledku
  • Šinkora, Jiří
  • Štěpánková, Renata
  • Čapková, Jana
  • Šinkorová, Z.
  • Niederlová, J.
http://linked.open...ain/vavai/riv/wos
  • 000261925100006
http://linked.open...n/vavai/riv/zamer
issn
  • 0198-8859
number of pages
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