About: Výzkum buněčné a molekulární biologie, genetiky, fyziologie a ekologie mikroorganizmů, mikrobní biotechnologie; studium imunitních procesů

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About: Výzkum buněčné a molekulární biologie, genetiky, fyziologie a ekologie mikroorganizmů, mikrobní biotechnologie; studium imunitních procesů Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Zamer, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Zamer
Description	Výzkum bude zaměřen na buněčnou a molekulární biologii, genetiku a fyziologii mikroorganizmů, rezistenci vůči antibiotikům, produkci mikrobních metabolitů a jejich biotransformace, šlechtění produkčních kmenů mikroorganizmů, ekologii mikroorganizmů a jejich biodegradačních aktivit. Dále bude studována vrozená a získaná imunita a regulace fyziologických a patologických imunitních procesů na buněčné a molekulární úrovni. Pozornost bude věnována jejich fylogenetickému a ontogenetickému vývoji v konvenčních a bezmikrobních podmínkách. Cílem záměru je přinést nové poznatky o biologii mikroorganizmů, o imunitních procesech a lépe pochopit časné evoluční stupně imunokompetence. Bude studován význam různých exogenních stresů na buněčnou energetiku a schopnost ABC pump vylučovat xenobiotika. Výsledkem bude hlubší pochopení základních vlastností mikroorganizmů a imunitních procesů a využití získaných poznatků v nových biotechnologiích a při terapii nádorových a imunitních onemocnění. Cellular and molecular biology, genetics and physiology of microorganisms and their resistance against antibiotics, production of microbial metabolites and their biotransformation, improvement of production strains and ecology of microorganisms and their biodegradation ability will be studied. Innate and acquired immunity, regulation of physiological and pathological immunological processes and their ontogenetic development under both conventional and germ-free conditions will also be investigated. It is the aim of the studies to bring new data on biology of microorganisms, immunological processes and to understand early stages in evolution of immune competence. Also, the effects of various types of exogenously applied stress on cell energetics will be studied.The research will result in a deeper understanding of general properties of microorganisms and immunological processes and in the utilization of the data in new biotechnologies and in therapy of tumor and autoimmune diseases. (en)
Title	Výzkum buněčné a molekulární biologie, genetiky, fyziologie a ekologie mikroorganizmů, mikrobní biotechnologie; studium imunitních procesů Study of cellular and molecular biology, genetics, physiology, ecology of microorganisms, microbial biotechnologies, investigation of immunological processes (en)
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/zamer/AV0Z5020903/celkovaStatniPodpora
http://linked.open...ez/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/zamer/AV0Z5020903/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2005-06-17 (xsd:date)
http://linked.open...vavai/cez/dodavka	http://linked.opendata.cz/resource/domain/vavai/dodavka/CEZ%2F2005%2FAV0%2FAV0500%2FU%2FN%2F3%3A1
http://linked.open...ez/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...in/vavai/cez/faze	33123750
http://linked.open...ai/cez/hlavniObor	EE - Mikrobiologie, virologie
http://linked.open...vai/cez/hodnoceni	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open.../cez/kategorieVaV	ZV - Základní výzkum
http://linked.open.../cez/klicovaSlova	microbiology;cellular and molecular biology;genetics;physiology;microbial metabolites;strain improvement;antibiotic resistance;ecology;biodegradation;biotechnology;immunology;immunopathology;tumor immunology;immunotherapy;oxidative stress (en)
http://linked.open...icUkonceniPodpory	1 (xsd:int)
http://linked.open...icZahajeniPodpory	1 (xsd:int)
http://linked.open...cez/partnerHlavni	Mikrobiologický ústav AV ČR, v.v.i.
http://linked.open...z/poceVysledkuRIV	1246 (xsd:int)
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cez/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open...enychVysledkuVRIV	1246 (xsd:int)
http://linked.open.../vavai/cez/resort	Academy of Sciences of the Czech Republic
http://linked.open...okUkonceniPodpory	2004
http://linked.open...okZahajeniPodpory	1999
http://linked.open...iciPoslednihoRoku	2005
http://linked.open...atUdajeProjZameru	2005
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open.../cez/vedlejsiObor	EB - Genetika a molekulární biologie EC - Imunologie
http://linked.open...n/vavai/cez/zamer	Z - Výzkumný záměr financovaný ze státního rozpočtu
http://linked.open...sledkuDodavatelem	Novel data on molecular and cell biology of studied microorganisms were achieved and new high-production strains were constructed. Immunological studies were focused on clinical application of targeted cytostatics and therapy of autoimmune diseases. (en) Byly získány nové poznatky o molekulární a buněčné biologii studovaných mikroorganizmů a byly vyšlechtěny nové vysokoprodukční kmeny. Imunologické studium bylo zaměřeno na klinické použití směrovaných cytostatik a na terapii autoimunitních onemocnění. (cs)
http://linked.open...cez/zivotniCyklus	ZBBBBKU
is http://linked.open...n/vavai/riv/zamer of	PIXE Determination of Element Distribution in Fomes Fomentarius The use of DGGE in ecology. What can be found by single-cell RT-PCR combined with routine flow cytometry? Is there anything new. Walking alongside the nucleoskeleton. Yeast as a model for ageing and apoptoses research. The W303 Genetic Background Affects the isw2delta Mutant Phenotype in Saccharomyces cerevisiae. Cytotoxic and immunostimulating activities of polymer-bound drugs Decolorization of synthetic dyes using a copper complex with glucaric acid Decolorization of Dyes using White-rot Fungi and Radical-generating Reactions Development of oxidoreductases production technology by expression in Escherichia coli high-density cultures Degradation of BTEX and PAHs by Co(II) and Cu(II)-based radical-generating systems Cultural characteristics, sexuality and ligninolytic enzyme production of Trametes cervina Construction of unmarked mutants in gene coding for Ser/Thr protein kinases and phosphoprotein phosphatase of Pseudomonas aeruginosa and analysis of theur properties Conversion of lactose to Beta-D-flactopyranosyl-(1-4)-D-arabino-hexos-2-ulose-(2-dehydrolactose) and lactobiono-1,5-lactone by fungal pyranose dehydeogenase Development of apoptotic features in Saccharomyces cerevisiae during aging Development of B thymocytes and gamma delta T cell during prenatal and postnatal ontogeny in pigs Differential Expression of IgVH mRNAs in Two B Cell Populations of Human RA Synovium Detected by Single-Cell RT-PCR Copper-ligand comlex for the decolorization of synthetic dyes Decontamination of waters polluted by copper ions using streptomyces noursei and candida utilis biomass Cryo-FE-SEM and TEM immuno-techniques reveal new details for understanding white-rot decay of lignocellulose Construction of corynebacterium glutamicum strains overproducing valine Cytotoxic and Immunomodulatory Activites of Polymer-bound Drugs Different strictuctural requirements for adenylate cyclase toxin interactions with erythrocyte and liposome membranes. Degradation of methyl-tert-butyl ether (MTBE). identification of heparin-binding sites in the fibronectin type III domains of the leukocyte common antigen (CD45) High-level expression of a fungal pyranose oxidase in high cell-density fed-batch cultivations of Escherichia coli using lactose as inducer Gliadin stimulates human monocytes to production of IL-8 and TNF-alfa through a mechanism involving NF-kB HPMA Copolymer-Bound Doxorubicin Targeted with Monoclonal Antibody to Tumor-Specific Antigen of BCL1 Leukemia Cells Can Comletely Cure Tumor-Bearing Mice and Establish Long-Term Immunological Memory to tje Original Tumor Growth-phase dependence of membrane potential and activity of major PDR pumps in S. cerevisiae GleNAc-Terminated Glycodendrimers Are Up-Taken by and Modulate NK cells Expressing NKR-P1 Receptor Generation of HSP60-specific IL-10 producing regulatory CD4+T ceels HPMA copolymers containing doxorubicin bound by a proteolytically or hydrolytically cleavable bond: comparison of biological properties in vitro he role of carbohydrate structures in NKR-P1-mediated effector-target cell interaction Functional Analogy of Vertebrate and Invertebrate Cytokine-like Molecules Without Structural Homology Identification of proteins associated with lipid rafts of Jurkat T-cell line by mass spectrometry Glycosidases - bizarre substrates and products ICP-MS determination of heavy metals in submerged cultures of wood-rotting fungi Genes coding for acetyhydroxy acid synthase in Streptomyces cinnamonensis and their regulatory region:Mutations in the catalytic subunit conferring insesitivity to end-product inhibition Hydrolytic and transglycosylation ractions of N-acyl modified substrates catalysed by Beta-N-acetylhexosaminidases. HPMA copolymers containing soxorubicin bound by inzymatically or hydrolytically cleavable bond: comparison of gene expression regulationg apoptosis and cell cycle in 38C13 and el4 cells. Long-term survival of Saccharomyces cerevisiae colonies: Role of Sok2p transcription factor Microarray-based identification of genes regulatrd by Ser/Thr protein kinase of Streptococcus pneumoniae Microarray-based identification of genes and 2-D gel analysis of proteins regulated by Ser/Thr protein kinase of Streptococcus pneumoniae Lycoperdinoside A and B, New Glycosides from the Slim Mold Enteridium lycoperdon Mass spectrometry as an important tool for structure elucidation of Beta-N-acetylhexosaminidase Microarray-based identification of genes regulated by ser/thr protein kinase of Streptococcus pneumoniae Makromycety v lidové i oficinální medicíně Mannan-Binding Lectin in Premature Infants:The Effect of Nosocomial Infection Mechanism of lytic activity of Eisenia Foetida earthworm defence molecule on mammalian cells Mass spectrometry-based strategies for protein identification and characterization Mass spectrometry: a universal tool for probing of protein glycosylation Mass spectrometry is a powerful tool for identification of proteins associated with lipid rafts of Jurkat T-cell line Lymphocyte activation receptors:new structural paradigms in group V of C-type animal lectins Mechanism of action of HPMA-based non-targeted polymeric prodrugs Mating tests among geographically separated collections of the Trametes versicolor (Fr.) Pilát (Basidiomycetes, Polyporales) group Lytophylippines A-C:novel macrolactones from the Red Sea hydroid Lytocarpus philippinus Mechanisms of resistance to macrolides and lincosamides in coagulase-negative Staphylococci in the Czech Republic and new type of lincosamide-resistance in S. haemolyticus Použití nové metody ARC-mikroskopie (azimutální reliéfní kontrast) k zobrazení mikroorganismů Preparation of Nanoparticles by Electroagulation From Soluble Exopolysaccharide Produced by Claviceps viridis. Anorexigenic effect of cholecystokinin is lost but that of CART (cocaine and amphetamine regulated transcript) peptide is preserved in monosodium glutamate obese mice Ice-age endurance: the effects of cryopreservation on proteins of sperm of common carp, Cyprinus carpio L Reactions of 2,4,4,6-tetraaryl-4H-thiopyrans with chlorine: an unusual reaction route. Enzymic synthesis and hydrolytic resolution of alkyl .beta.-D-glucopyranosides. Enzymatic rearrangement of chitine hydrolysates with .beta.-N-acetylhexosaminidase from Aspergillus oryzae. Enzymatic synthesis of three pNP-alpha-galactobiopyranosides: application of the library of fungal alpha-galactosidases.

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