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  • However cytostatic polymeric conjugates based on N-(2-hydroxypropyl)methacrylamide are in clinical trials, we are still far away from understanding the mechanism of their action. Cleavability of the drug from oligopeptidic side-chains of polymeric carriers seems not to be necessary condition for pharmacological activity and those spacers play most probably a very important role in the accumulation of conjugates in tumor cells.
  • However cytostatic polymeric conjugates based on N-(2-hydroxypropyl)methacrylamide are in clinical trials, we are still far away from understanding the mechanism of their action. Cleavability of the drug from oligopeptidic side-chains of polymeric carriers seems not to be necessary condition for pharmacological activity and those spacers play most probably a very important role in the accumulation of conjugates in tumor cells. (en)
  • Ačkoliv cytostatické polymerní konjugáty na bázi N-(2-hydroxypropyl)metakrylamidu jsou již ve fázi preklinických testů, skutečný mechanismus jejich účinku není ještě zcela objasněn. Zdá se že štěpitelnost postranních peptidických řetězců nesoucích cytostatikum není podmínkou účinnosti těchto konjugátů a tyto řetězce jsou zodpovědné spíše za masivní akumulaci těchto léčiv v nádorových buňkách. (cs)
Title
  • Mechanism of action of HPMA-based non-targeted polymeric prodrugs
  • Mechanism of action of HPMA-based non-targeted polymeric prodrugs (en)
  • Mechanismus působení polymerních léčiv na bázi HPMA (cs)
skos:prefLabel
  • Mechanism of action of HPMA-based non-targeted polymeric prodrugs
  • Mechanism of action of HPMA-based non-targeted polymeric prodrugs (en)
  • Mechanismus působení polymerních léčiv na bázi HPMA (cs)
skos:notation
  • RIV/61388971:_____/04:00108060!RIV/2005/AV0/A53005/N
http://linked.open.../vavai/riv/strany
  • 171
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z5020903)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
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  • 572737
http://linked.open...ai/riv/idVysledku
  • RIV/61388971:_____/04:00108060
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • hpma-dox; hpma-based (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [944A6AFD6F3E]
http://linked.open...v/mistoKonaniAkce
  • Praha
http://linked.open...i/riv/mistoVydani
  • Praha
http://linked.open...i/riv/nazevZdroje
  • International Conference on Tumor Microenvironment:Progression, Therapy and Prevention /3./
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Etrych, Tomáš
  • Strohalm, Jiří
  • Ulbrich, Karel
  • Říhová, Blanka
  • Šubr, Vladimír
  • Bouček, Jan
  • Hovorka, Ondřej
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
http://linked.open...n/vavai/riv/zamer
number of pages
http://purl.org/ne...btex#hasPublisher
  • Neuveden
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