About: Mouse 3T3 fibroblasts under the influence of fibroblasts isolated from stroma of human basal cell carcinoma acquire properties of multipotent stem cells

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Multipotent mesenchymal stem cells can participate in the formation of a microenvironment stimulating the aggressive behaviour of cancer cells. Cells exhibiting pluripotent embryonic stem cell markers (Nanog and Oct4) have been observed in many tumours. Here, we investigate the stem cell supporting role of cancer-associated fibroblasts (CAF). We test the influence of CAF isolated from basal cell carcinoma on mouse 3T3 fibroblasts, focusing on the expression of stem cell markers and plasticity in vitro. We demonstrate the biological activity of CAF by influencing the 3T3 fibroblasts to express markers such as Oct4, Nanog and Sox2 and to show differentiation potential similar to mesenchymal stem cells. The role of growth factors such as IGF2, FGF7, LEP, NGF and TGFβ, produced by CAF, is established to participate in their activity. Our observations indicate the pro-stem cell activity of CAF and underline the role of epithelial–mesenchymal interaction in tumour biology. Multipotent mesenchymal stem cells can participate in the formation of a microenvironment stimulating the aggressive behaviour of cancer cells. Cells exhibiting pluripotent embryonic stem cell markers (Nanog and Oct4) have been observed in many tumours. Here, we investigate the stem cell supporting role of cancer-associated fibroblasts (CAF). We test the influence of CAF isolated from basal cell carcinoma on mouse 3T3 fibroblasts, focusing on the expression of stem cell markers and plasticity in vitro. We demonstrate the biological activity of CAF by influencing the 3T3 fibroblasts to express markers such as Oct4, Nanog and Sox2 and to show differentiation potential similar to mesenchymal stem cells. The role of growth factors such as IGF2, FGF7, LEP, NGF and TGFβ, produced by CAF, is established to participate in their activity. Our observations indicate the pro-stem cell activity of CAF and underline the role of epithelial–mesenchymal interaction in tumour biology. (en)
Title	Mouse 3T3 fibroblasts under the influence of fibroblasts isolated from stroma of human basal cell carcinoma acquire properties of multipotent stem cells Mouse 3T3 fibroblasts under the influence of fibroblasts isolated from stroma of human basal cell carcinoma acquire properties of multipotent stem cells (en)
skos:prefLabel	Mouse 3T3 fibroblasts under the influence of fibroblasts isolated from stroma of human basal cell carcinoma acquire properties of multipotent stem cells Mouse 3T3 fibroblasts under the influence of fibroblasts isolated from stroma of human basal cell carcinoma acquire properties of multipotent stem cells (en)
skos:notation	RIV/68378050:_____/11:00365189!RIV12-AV0-68378050
http://linked.open...avai/predkladatel	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(1M0520), P(1M0538), P(2B06106), S, Z(AV0Z50520514), Z(MSM0021620806)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Szabo, Pavol Strnad, Hynek Vlček, Čestmír Kolář, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	213853
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/11:00365189
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	basal cell carcinoma (BCC); stem cell; tumour stroma (en)
http://linked.open.../riv/klicoveSlovo	stem cell basal cell carcinoma (BCC) tumour stroma
http://linked.open...odStatuVydavatele	FR - Francouzská republika
http://linked.open...ontrolniKodProRIV	[A810AFA4C570]
http://linked.open...i/riv/nazevZdroje	Biology of the Cell
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Novel genomic and biotechlological approaches in molecular oncology: a way to the early diagnostics and targeted therapy Center for Applied Genomics Center for Cell Therapy and Tissue Repair
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	103
http://linked.open...iv/tvurceVysledku	Kolář, Michal Strnad, Hynek Vlček, Čestmír Szabo, Pavol Dvořánková, B. Lacina, L. Smetana, K. Tvrdek, M. Štork, J.
http://linked.open...ain/vavai/riv/wos	000292430900003
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů
issn	0248-4900
number of pages	16 (xsd:int)
http://bibframe.org/vocab/doi	10.1042/BC20100113
is http://linked.open...avai/riv/vysledek of	Mouse 3T3 fibroblasts under the influence of fibroblasts isolated from stroma of human basal cell carcinoma acquire properties of multipotent stem cells Mouse 3T3 fibroblasts under the influence of fibroblasts isolated from stroma of human basal cell carcinoma acquire properties of multipotent stem cells

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