About: Molecular analysis of the HIV-1 resistance development: Enzymatic activities, crystal structures, and thermodynamics of nelfinavir-resistant HIV protease mutants

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This work describes the structure, inhibition profile and microcalorimetric analyses of a series of nelfinavir-resistant HIV protease mutants. The structural aspects of the antiviral resistance development are explained and a theoretical model, enabling resistance predictions is proposed. This work describes the structure, inhibition profile and microcalorimetric analyses of a series of nelfinavir-resistant HIV protease mutants. The structural aspects of the antiviral resistance development are explained and a theoretical model, enabling resistance predictions is proposed. (en) Práce popisuje strukturu, aktivitu, inhibiční profil a mikrokalorimetrickou analysu serie mutantů HIV proteasy, resistentních vůči proteasovému inhibitoru nelfinaviru. Jsou vysvětlovány strukturní aspekty vývoje protivirové resistence a navržen teoretický model, umožňující predikci resistence. (cs)
Title	Molecular analysis of the HIV-1 resistance development: Enzymatic activities, crystal structures, and thermodynamics of nelfinavir-resistant HIV protease mutants Molekulární analysa vývoje resistence u HIV-1: enzymatické aktivity, krystalové struktury a termodynamika mutantů HIV-1 proteasy resistentních k nelfinaviru (cs) Molecular analysis of the HIV-1 resistance development: Enzymatic activities, crystal structures, and thermodynamics of nelfinavir-resistant HIV protease mutants (en)
skos:prefLabel	Molecular analysis of the HIV-1 resistance development: Enzymatic activities, crystal structures, and thermodynamics of nelfinavir-resistant HIV protease mutants Molekulární analysa vývoje resistence u HIV-1: enzymatické aktivity, krystalové struktury a termodynamika mutantů HIV-1 proteasy resistentních k nelfinaviru (cs) Molecular analysis of the HIV-1 resistance development: Enzymatic activities, crystal structures, and thermodynamics of nelfinavir-resistant HIV protease mutants (en)
skos:notation	RIV/68378050:_____/07:00089788!RIV08-AV0-68378050
http://linked.open.../vavai/riv/strany	1005;1016
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0508), P(LC512), P(NR8571), Z(AV0Z40550506), Z(AV0Z50520514), Z(MSM 113100001)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Řezáčová, Pavlína
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	434831
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/07:00089788
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HIV protease inhibitors; protease-inhibitor structure; isothermal calorimetry; antiviral resistance development (en)
http://linked.open.../riv/klicoveSlovo	HIV protease inhibitors protease-inhibitor structure isothermal calorimetry antiviral resistance development
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[C8079E0903BD]
http://linked.open...i/riv/nazevZdroje	Journal of Molecular Biology
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	New Antivirals and Antineoplastics Center for biomolecules and complex molecular systems Molecular characterisation of resistant mutants of viral protease from HIV-positive patients developed under the selection pressure of protease inhibitors: design of novel inhibitors and diagnostics for individualised molecular medicine
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	374
http://linked.open...iv/tvurceVysledku	Brynda, Jiří Konvalinka, Jan Kožíšek, Milan Pokorná, Jana Rulíšek, Lubomír Řezáčová, Pavlína Šašková, Klára Bray, J. Mammano, F.
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20113100001
issn	0022-2836
number of pages	12 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Molecular analysis of the HIV-1 resistance development: Enzymatic activities, crystal structures, and thermodynamics of nelfinavir-resistant HIV protease mutants Molecular analysis of the HIV-1 resistance development: Enzymatic activities, crystal structures, and thermodynamics of nelfinavir-resistant HIV protease mutants Molecular analysis of the HIV-1 resistance development: Enzymatic activities, crystal structures, and thermodynamics of nelfinavir-resistant HIV protease mutants

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