About: Molecular characterisation of resistant mutants of viral protease from HIV-positive patients developed under the selection pressure of protease inhibitors: design of novel inhibitors and diagnostics for individualised molecular medicine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

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Description
  • The project involves analysis of resistance development in HIV-positive patients treated by protease inhibitors in the CR, design of novel, non-infectious phenotypic resistance assays and design of novel inhibitors, active against resistant forms of HIV. (en)
  • Projekt navrhuje sledování vzniku resistence u HIV-positivních pacientů v ČR, vývoj nových, jednoduchých neinfekčních metod testování resistence a návrh nových strukturních typů inhibitorů, aktivních vůči resistentním formám HIV.
Title
  • Molecular characterisation of resistant mutants of viral protease from HIV-positive patients developed under the selection pressure of protease inhibitors: design of novel inhibitors and diagnostics for individualised molecular medicine (en)
  • Molekulární charakterisace resistentních forem virové proteasy z HIV-positivních pacientů vzniklých pod selekčním tlakem inhibitorů proteasy: návrh nových inhibitorů a diagnostických postupů pro individualisovanou molekulární medicínu
skos:notation
  • NR8571
http://linked.open...avai/cep/aktivita
http://linked.open...kovaStatniPodpora
http://linked.open...ep/celkoveNaklady
http://linked.open...datumDodatniDoRIV
http://linked.open...i/cep/druhSouteze
http://linked.open...ep/duvernostUdaju
http://linked.open.../cep/fazeProjektu
http://linked.open...ai/cep/hlavniObor
http://linked.open...hodnoceniProjektu
http://linked.open...vai/cep/kategorie
http://linked.open.../cep/klicovaSlova
  • HIV; protease; sequencing; inhibitor; resistance; mutation; therapy; AIDS (en)
http://linked.open...ep/partnetrHlavni
http://linked.open...inujicichPrijemcu
http://linked.open...cep/pocetPrijemcu
http://linked.open...ocetSpoluPrijemcu
http://linked.open.../pocetVysledkuRIV
http://linked.open...enychVysledkuVRIV
http://linked.open...lneniVMinulemRoce
http://linked.open.../prideleniPodpory
http://linked.open...iciPoslednihoRoku
http://linked.open...atUdajeProjZameru
http://linked.open.../vavai/cep/soutez
http://linked.open...usZobrazovaneFaze
http://linked.open...ai/cep/typPojektu
http://linked.open...ep/ukonceniReseni
http://linked.open.../cep/vedlejsiObor
http://linked.open...ep/zahajeniReseni
http://linked.open...jektu+dodavatelem
  • Kombinací molekulárně biologických, strukturálních a enzymologických metod byl charakterizován vznik rezistence HIV vůči inhibitorům proteáz. Navrženy nové sloučeniny /metallakarborany/ inhibující mutantní proteázy. (cs)
  • Combination of molecularly biological structural and enzymological methods characterized the origin of HIV resistance of HIV against inhibitors of proteases. New compounds /metallacarborans/ inhiting mutant proteases (en)
http://linked.open...tniCyklusProjektu
http://linked.open.../cep/klicoveSlovo
  • HIV
  • inhibitor
  • mutation
  • protease
  • resistance
  • sequencing
  • therapy
is http://linked.open...vavai/riv/projekt of
is http://linked.open...vavai/cep/projekt of
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