| Attributes | Values |
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| rdf:type
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| Description
| - Syncytin-1 is a captive envelope glycoprotein encoded by one of human endogenous retroviruses W. It is expressed exclusively in the placental trophoblast where it participates in cell-to-cell fusion during differentiation of syncytiotrophoblast. In other tissues, however, syncytin-1 expression must be kept in check because inadvertent cell fusion might be dangerous for tissue organization and integrity. We describe here an inverse correlation between CpG methylation of syncytin-1 5' long terminal repeat and its expression. Our data on syncytin-1 methylation in the placenta, other primary cells and cell lines non-expressing syncytin-1 document that CpG methylation plays a principal role in the transcriptional suppression of syncytin-1 in non-placental tissues, and, in contrast, demethylation of the syncytin-1 promoter in trophoblast is a prerequisite for its expression and differentiation of multinucleated syncytiotrophoblast.
- Syncytin-1 is a captive envelope glycoprotein encoded by one of human endogenous retroviruses W. It is expressed exclusively in the placental trophoblast where it participates in cell-to-cell fusion during differentiation of syncytiotrophoblast. In other tissues, however, syncytin-1 expression must be kept in check because inadvertent cell fusion might be dangerous for tissue organization and integrity. We describe here an inverse correlation between CpG methylation of syncytin-1 5' long terminal repeat and its expression. Our data on syncytin-1 methylation in the placenta, other primary cells and cell lines non-expressing syncytin-1 document that CpG methylation plays a principal role in the transcriptional suppression of syncytin-1 in non-placental tissues, and, in contrast, demethylation of the syncytin-1 promoter in trophoblast is a prerequisite for its expression and differentiation of multinucleated syncytiotrophoblast. (en)
- Syncytin-1 je obalový glykoprotein kódovaný jedním z lidských endogenních retrovirů W. Je exprimován výhradně v placentálním trofoblastu, kde se účastní splývání buněk při diferenciaci syncytiotrofoblastu. V jiných tkáních však musí být exprese syncytinu-1 přísně regulována, protože náhodné fúze buněk by mohly ohrozit organizaci a integritu tkání. Popisujeme zde opačný vztah metylace CpG 5' dlouhé koncové repetice syncytinu-1 k jeho expresi. Naše údaje o metylaci syncytinu-1 v placentě, jiných primárních buňkách a buněčných liniích neexprimujících syncytin-1 ukazují, že metylace CpG hraje zásadní roli v potlačení transkripce syncytinu-1 v neplacentálních tkáních a naopak, demetylace promotoru syncytinu-1 v trofoblastu je základním předpokladem pro jeho expresi a pro diferenciaci mnohajaderného syncytiotrofoblastu. (cs)
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| Title
| - CpG methylation suppresses transcriptional activity of human syncytin-1 in non-placental tissues
- CpG methylation suppresses transcriptional activity of human syncytin-1 in non-placental tissues (en)
- Metylace CpG potlačuje transkripční aktivitu lidského syncytinu-1 v neplacentálních tkáních (cs)
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| skos:prefLabel
| - CpG methylation suppresses transcriptional activity of human syncytin-1 in non-placental tissues
- CpG methylation suppresses transcriptional activity of human syncytin-1 in non-placental tissues (en)
- Metylace CpG potlačuje transkripční aktivitu lidského syncytinu-1 v neplacentálních tkáních (cs)
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| skos:notation
| - RIV/68378050:_____/06:00030963!RIV06-AV0-68378050
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(GA204/05/0939), P(IAA5052207), Z(AV0Z50520514)
|
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/06:00030963
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - syncytin-1; trophoblast; DNA methylation (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Experimental Cell Research
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Blažková, Jana
- Hejnar, Jiří
- Matoušková, Magda
- Pajer, Petr
- Pavlíček, Adam
|
| http://linked.open...n/vavai/riv/zamer
| |
| issn
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| number of pages
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| is http://linked.open...avai/riv/vysledek
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