About: The interplay of the aryl hydrocarbon receptor and beta-catenin alters both AhR-dependent transcription and Wnt/beta-catenin signaling in liver progenitors

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The interplay of the aryl hydrocarbon receptor and beta-catenin alters both AhR-dependent transcription and Wnt/beta-catenin signaling in liver progenitors Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Beta-catenin is a key integrator of cadherin-mediated cell-cell adhesion and transcriptional regulation through the Wnt/beta-catenin pathway, which plays an important role in liver biology. In the present study, we showed that, although beta-catenin may augment the expression of selected target genes of the AhR, a transcriptional factor mediating toxic effects of persistent organic pollutants, the AhR activation may lead to downregulation of Wnt/beta-catenin signaling, and alterations in differentiation and/or proliferative status of liver progenitor cells. Beta-catenin is a key integrator of cadherin-mediated cell-cell adhesion and transcriptional regulation through the Wnt/beta-catenin pathway, which plays an important role in liver biology. In the present study, we showed that, although beta-catenin may augment the expression of selected target genes of the AhR, a transcriptional factor mediating toxic effects of persistent organic pollutants, the AhR activation may lead to downregulation of Wnt/beta-catenin signaling, and alterations in differentiation and/or proliferative status of liver progenitor cells. (en)
Title	The interplay of the aryl hydrocarbon receptor and beta-catenin alters both AhR-dependent transcription and Wnt/beta-catenin signaling in liver progenitors The interplay of the aryl hydrocarbon receptor and beta-catenin alters both AhR-dependent transcription and Wnt/beta-catenin signaling in liver progenitors (en)
skos:prefLabel	The interplay of the aryl hydrocarbon receptor and beta-catenin alters both AhR-dependent transcription and Wnt/beta-catenin signaling in liver progenitors The interplay of the aryl hydrocarbon receptor and beta-catenin alters both AhR-dependent transcription and Wnt/beta-catenin signaling in liver progenitors (en)
skos:notation	RIV/68081707:_____/11:00366424!RIV12-AV0-68081707
http://linked.open...avai/predkladatel	Biofyzikální ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA524/09/1337), P(GD204/09/H058), Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM0021622430), Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Umannová, Lenka Kozubík, Alois Vondráček, Jan Procházková, Jiřina Bryja, Vítězslav Kabátková, Markéta
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	205482
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/11:00366424
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	dioxin; beta-catenin; AhR (en)
http://linked.open.../riv/klicoveSlovo	beta-catenin dioxin AhR
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[142EC5AD4BE8]
http://linked.open...i/riv/nazevZdroje	Toxicological Sciences
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Interactions of Wnt and Ah receptor signaling in regulation of functions of liver cells Intercellular signalling in development and disease
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	122
http://linked.open...iv/tvurceVysledku	Bryja, Vítězslav Kozubík, Alois Machala, M. Procházková, Jiřina Umannová, Lenka Vondráček, Jan Bernatík, O. Kabátková, Markéta
http://linked.open...ain/vavai/riv/wos	000293914500011
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies Animal disease research, prevention and food chain protection
issn	1096-6080
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1093/toxsci/kfr129
is http://linked.open...avai/riv/vysledek of	The interplay of the aryl hydrocarbon receptor and beta-catenin alters both AhR-dependent transcription and Wnt/beta-catenin signaling in liver progenitors The interplay of the aryl hydrocarbon receptor and beta-catenin alters both AhR-dependent transcription and Wnt/beta-catenin signaling in liver progenitors

Faceted Search & Find service v1.16.116 as of Feb 22 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3239 as of Feb 22 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 68 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software