About: The effect of lipid peroxidation products on reactive oxygen species formation and nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of the present study was to investigate the effects of lipid peroxidation products (LPPs) - acrolein, 4-hydroxynonenal, and malondialdehyde - on ROS and NO production in RAW 264.7 macrophages. Our study shows that the cytotoxic action of acrolein and 4-hydroxynonenal works in a dose- and timedependent manner. Moreover, LPPs can inhibit ROS and NO production partially independently of their toxic effect. Changes in enzymatic pathways and NO scavenging properties are included in the downregulation of reactive species formation. The aim of the present study was to investigate the effects of lipid peroxidation products (LPPs) - acrolein, 4-hydroxynonenal, and malondialdehyde - on ROS and NO production in RAW 264.7 macrophages. Our study shows that the cytotoxic action of acrolein and 4-hydroxynonenal works in a dose- and timedependent manner. Moreover, LPPs can inhibit ROS and NO production partially independently of their toxic effect. Changes in enzymatic pathways and NO scavenging properties are included in the downregulation of reactive species formation. (en)
Title	The effect of lipid peroxidation products on reactive oxygen species formation and nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages The effect of lipid peroxidation products on reactive oxygen species formation and nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages (en)
skos:prefLabel	The effect of lipid peroxidation products on reactive oxygen species formation and nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages The effect of lipid peroxidation products on reactive oxygen species formation and nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages (en)
skos:notation	RIV/68081707:_____/11:00358792!RIV12-AV0-68081707
http://linked.open...avai/predkladatel	Biofyzikální ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA524/08/1753), P(OC08058), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Lojek, Antonín Ambrožová, Gabriela Pekarová, Michaela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	196332
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/11:00358792
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	lipid peroxidation products; reactive oxygen species; nitric oxide (en)
http://linked.open.../riv/klicoveSlovo	lipid peroxidation products nitric oxide reactive oxygen species
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[B8797AAFBB4A]
http://linked.open...i/riv/nazevZdroje	Toxicology in Vitro
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	The influence of L-arginine and its analogues on the generation of reactive oxygen and nitrogen species by professional phagocytes Effects of polyunsaturated fatty acids and their metabolites on the physiological functions of professional phagocytes
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	25
http://linked.open...iv/tvurceVysledku	Lojek, Antonín Pekarová, Michaela Ambrožová, Gabriela
http://linked.open...ain/vavai/riv/wos	000287010600019
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0887-2333
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.tiv.2010.10.006
is http://linked.open...avai/riv/vysledek of	The effect of lipid peroxidation products on reactive oxygen species formation and nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages The effect of lipid peroxidation products on reactive oxygen species formation and nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages

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