About: FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence

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About: FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	FGFR3 signaling is capable of inducing premature senescence in chondrocytes, manifested as reversible, ERK-dependent growth arrest accompanied by alteration of cellular shape, loss of the extracellular matrix, upregulation of senescence markers (alpha-GLUCOSIDASE, FIBRONECTIN, CAVEOLIN 1, LAMIN A, SM22alpha and TIMP 1), and induction of senescence-associated beta-GALACTOSIDASE activity. Our data support a model whereby FGFR3 signaling inhibits cartilage growth via exploiting cellular response originally designed to eliminate cells harboring activated oncogenes. FGFR3 signaling is capable of inducing premature senescence in chondrocytes, manifested as reversible, ERK-dependent growth arrest accompanied by alteration of cellular shape, loss of the extracellular matrix, upregulation of senescence markers (alpha-GLUCOSIDASE, FIBRONECTIN, CAVEOLIN 1, LAMIN A, SM22alpha and TIMP 1), and induction of senescence-associated beta-GALACTOSIDASE activity. Our data support a model whereby FGFR3 signaling inhibits cartilage growth via exploiting cellular response originally designed to eliminate cells harboring activated oncogenes. (en)
Title	FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence (en)
skos:prefLabel	FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence (en)
skos:notation	RIV/68081707:_____/10:00345306!RIV11-AV0-68081707
http://linked.open...avai/riv/aktivita	P S V Z
http://linked.open...avai/riv/aktivity	P(GA301/09/0587), S, V, Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kozubík, Alois Bryja, Vítězslav Krejčí, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	259031
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/10:00345306
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	FGFR3; oncogene; skeletal dysplasia (en)
http://linked.open.../riv/klicoveSlovo	oncogene skeletal dysplasia FGFR3
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[D659A21CF5F2]
http://linked.open...i/riv/nazevZdroje	Bone
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Novel pathways of FGFR3 signaling in achondroplasia
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	47
http://linked.open...iv/tvurceVysledku	Bryja, Vítězslav Kozubík, Alois Krejčí, Pavel Procházková, J. Wilcox, W. R. Smutný, J. Aklian, A. Chlebová, K. Lin, P.
http://linked.open...ain/vavai/riv/wos	000279150400012
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	8756-3282
number of pages	9 (xsd:int)
is http://linked.open...avai/riv/vysledek of	FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence

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