About: DNA topology influences p53 sequence-specific DNA binding through structural transitions within the target sites

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Binding of p53 to any DNA increased with increasing negative superhelix density. The p53 target sequences possessing the inverted-repeat symmetry were shown to form cruciform structure in sufficiently negative scDNA. We show that formation of the cruciforms in DNA topoisomers at - > 0.05 correlates with the extra enhancement of p53-DNA binding. Binding of p53 to any DNA increased with increasing negative superhelix density. The p53 target sequences possessing the inverted-repeat symmetry were shown to form cruciform structure in sufficiently negative scDNA. We show that formation of the cruciforms in DNA topoisomers at - > 0.05 correlates with the extra enhancement of p53-DNA binding. (en) Vazba proteinu p53 na DNA se zlepšuje se zvyšováním negativní supergelikální hustoty DNA. Cílové sekvence proteinu p53 s inverzní repetitivní sekvencí vytváří v scDNA křížové struktury. Vytváření křížové struktury u DNA topoizomerů - > 0.05 koreluje s výrazným zvýšením vazby proteinu p53 k DNA. (cs)
Title	DNA topology influences p53 sequence-specific DNA binding through structural transitions within the target sites Topologie DNA ovlivňuje sekvenčně specifickou vazbu proteinu p53 strukturálními změnami v cílové sekvenci (cs) DNA topology influences p53 sequence-specific DNA binding through structural transitions within the target sites (en)
skos:prefLabel	DNA topology influences p53 sequence-specific DNA binding through structural transitions within the target sites Topologie DNA ovlivňuje sekvenčně specifickou vazbu proteinu p53 strukturálními změnami v cílové sekvenci (cs) DNA topology influences p53 sequence-specific DNA binding through structural transitions within the target sites (en)
skos:notation	RIV/68081707:_____/08:00309774!RIV09-AV0-68081707
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA301/05/0416), P(GP301/07/P160), P(IAA500040513), P(IAA500040701), P(KJB500040502), S, Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Paleček, Emil Fojta, Miroslav Jagelská, Eva Brázda, Václav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	364048
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/08:00309774
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	p53 protein; DNA binding; protein-DNA complex (en)
http://linked.open.../riv/klicoveSlovo	p53 protein protein-DNA complex DNA binding
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[33437A278C79]
http://linked.open...i/riv/nazevZdroje	Biochemical Journal
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of novel therapeutic strategies through sensitising tumour cells to anti-cancer drugs by targeting p53-kinases and p53 homologues Study of posttranslation modification of the tumor suppressor protein p53, its homologues and interacting proteins in human cancer cell lines Wild type and mutant p53 tumor suppressor protein. Intermolecular interactions, changes in conformation and new micro-methods of their analysis Interactions of wild type and mutant p53 proteins with damaged DNA and their roles in cellular response to anticancer chemotherapy Mutants of tumor supressor protein p53 and regulation of thei DNA binding activity
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	412
http://linked.open...iv/tvurceVysledku	Brázda, Václav Fojta, Miroslav Paleček, Emil Brázdová Jagelská, Eva Pečinka, P.
http://linked.open...ain/vavai/riv/wos	000256049800006
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0264-6021
number of pages	7 (xsd:int)
is http://linked.open...avai/riv/vysledek of	DNA topology influences p53 sequence-specific DNA binding through structural transitions within the target sites DNA topology influences p53 sequence-specific DNA binding through structural transitions within the target sites

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