About: Genome-Wide Co-Expression Analysis in Multiple Tissues

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Expresní lokusy kvantitativních znaků (eQTL, expression quantitative trait loci) představují genetické determinanty genové exprese, které lze rozdělit na cis a trans regulované. Zmapovali jsme tisíce cis a trans regulovaných eQTL ve čtyřech tkáních (tuk, ledvina, nadledvina a levá komora srdeční) u početného panelu rekombinantních inbredních kmenů. V této studii jsme analyzovali celogenomovou korelační strukturu eQTL transkriptů a podmiňujících genotypů s cílem odhalit povahu koregulací cis a trans regulovaných eQTL v jednotlivých tkáních (cs) Expression quantitative trait loci (eQTLs) represent genetic control points of gene expression, and can be categorized as cis and trans-acting, reflecting local and distant regulation of gene expression respectively. We have mapped thousands of cis- and trans-eQTLs in four tissues (fat, kidney, adrenal and left ventricle) in a large panel of rat recombinant inbred (RI) strains. Here we investigate the genome-wide correlation structure in expression levels of eQTL transcripts and underlying genotypes to elucidate the nature of co-regulation within cis- and trans-eQTL datasets Expression quantitative trait loci (eQTLs) represent genetic control points of gene expression, and can be categorized as cis and trans-acting, reflecting local and distant regulation of gene expression respectively. We have mapped thousands of cis- and trans-eQTLs in four tissues (fat, kidney, adrenal and left ventricle) in a large panel of rat recombinant inbred (RI) strains. Here we investigate the genome-wide correlation structure in expression levels of eQTL transcripts and underlying genotypes to elucidate the nature of co-regulation within cis- and trans-eQTL datasets (en)
Title	Genome-Wide Co-Expression Analysis in Multiple Tissues Genome-Wide Co-Expression Analysis in Multiple Tissues (en) Celogenomová koexpresní analýza v několika tkáních (cs)
skos:prefLabel	Genome-Wide Co-Expression Analysis in Multiple Tissues Genome-Wide Co-Expression Analysis in Multiple Tissues (en) Celogenomová koexpresní analýza v několika tkáních (cs)
skos:notation	RIV/67985823:_____/08:00318235!RIV09-AV0-67985823
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0520), P(1P05ME791), P(GA301/06/0028), P(GA301/08/0166), P(ME08006), Z(AV0Z50110509), Z(MSM0021620807)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Pravenec, Michal Křen, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	369170
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/08:00318235
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cis- and trans-eQTL; coexpression analysis in multiple tissues; recombinant inbred strains (en)
http://linked.open.../riv/klicoveSlovo	recombinant inbred strains Cis- and trans-eQTL coexpression analysis in multiple tissues
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[48D501CF4A48]
http://linked.open...i/riv/nazevZdroje	PLoS ONE
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Positional cloning of a gene on chromosome 10 that is responsible for hypertension and metabolic defects in the spontaneously hypertensive rat Genetic analysis of the role of mitochondria in the pathogenesis of metabolic syndrome studied in new rat conplastic strains Center for Applied Genomics Genetic determinants of cardiac mass and response to infarction in recombinant inbred rats Genetic and correlation analyses of ectopic fat accumulation and adipose tissue oxidative/inflammatory processes and their role in the pathogenesis of insulin resistance
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	3
http://linked.open...iv/tvurceVysledku	Křen, Vladimír Pravenec, Michal Cook, S. A. Hubner, N. Petretto, E. Aitman, T. J. Dickens, N. J. Grieve, I. C. Mangion, J.
http://linked.open...n/vavai/riv/zamer	Metabolické, endokrinní a genetické aspekty prevence, diagnostiky a terapie kardiovaskulárních, cerebrovaskulárních a renovaskulárních onemocnění Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	1932-6203
number of pages	11 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Genome-Wide Co-Expression Analysis in Multiple Tissues Genome-Wide Co-Expression Analysis in Multiple Tissues

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