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  • Free radicals generated during peroxidase-catalyzed oxidation of two xenobiotics, carcinogenic Sudan I and an anticancer agent ellipticine, easily attack unmodified proteins but not glycoproteins. A significant inverse correlation between the extent of glycosylation of proteins and the degree of binding of Sudan I or ellipticine radicals to these proteins was observed, whereby the protection only occurs if oligosaccharides are covalently bound to the proteins
  • Free radicals generated during peroxidase-catalyzed oxidation of two xenobiotics, carcinogenic Sudan I and an anticancer agent ellipticine, easily attack unmodified proteins but not glycoproteins. A significant inverse correlation between the extent of glycosylation of proteins and the degree of binding of Sudan I or ellipticine radicals to these proteins was observed, whereby the protection only occurs if oligosaccharides are covalently bound to the proteins (en)
Title
  • Glycosylation protects proteins against free radicals generated from toxic xenobiotics
  • Glycosylation protects proteins against free radicals generated from toxic xenobiotics (en)
skos:prefLabel
  • Glycosylation protects proteins against free radicals generated from toxic xenobiotics
  • Glycosylation protects proteins against free radicals generated from toxic xenobiotics (en)
skos:notation
  • RIV/61388971:_____/10:00350771!RIV11-GA0-61388971
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0505), P(GA203/09/0812), P(GA303/09/0477), P(GAP301/10/0356), Z(AV0Z40550506), Z(AV0Z50200510), Z(MSM0021620808)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 260855
http://linked.open...ai/riv/idVysledku
  • RIV/61388971:_____/10:00350771
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • hrp; sudan I; ellipticine (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [DE56DE6A5A55]
http://linked.open...i/riv/nazevZdroje
  • Toxicological Sciences
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 117
http://linked.open...iv/tvurceVysledku
  • Dračínský, Martin
  • Hofbauerová, Kateřina
  • Sklenář, Jan
  • Frei, E.
  • Šulc, M.
  • Bezouška, K.
  • Stiborová, M.
  • Martínek, V.
http://linked.open...ain/vavai/riv/wos
  • 000282055900012
http://linked.open...n/vavai/riv/zamer
issn
  • 1096-6080
number of pages
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