About: MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Elevated levels of microRNA miR-155 represent a candidate pathogenic factor in chronic B-lymphocytic leukemia (B-CLL). In this study, we present evidence that MYB (v-myb myeloblastosis viral oncogene homolog) is overexpressed in a subset of B-CLL patients. MYB physically associates with the promoter of miR-155 host gene (MIR155HG, also known as BIC, B-cell integration cluster) and stimulates its transcription. This coincides with the hypermethylated histone H3K4 residue and spread hyperacetylation of H3K9 at MIR155HG promoter. Our data provide evidence of oncogenic activities of MYB in B-CLL that include its stimulatory role in MIR155HG transcription. Elevated levels of microRNA miR-155 represent a candidate pathogenic factor in chronic B-lymphocytic leukemia (B-CLL). In this study, we present evidence that MYB (v-myb myeloblastosis viral oncogene homolog) is overexpressed in a subset of B-CLL patients. MYB physically associates with the promoter of miR-155 host gene (MIR155HG, also known as BIC, B-cell integration cluster) and stimulates its transcription. This coincides with the hypermethylated histone H3K4 residue and spread hyperacetylation of H3K9 at MIR155HG promoter. Our data provide evidence of oncogenic activities of MYB in B-CLL that include its stimulatory role in MIR155HG transcription. (en)
Title	MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia (en)
skos:prefLabel	MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia (en)
skos:notation	RIV/00216224:14740/11:00056976!RIV12-MZ0-14740___
http://linked.open...avai/predkladatel	Středoevropský technologický institut
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(2B06077), P(FR-TI2/509), P(LC06044), P(NS10310), P(NT11218), S, Z(MSM0021620806), Z(MSM0021620808)
http://linked.open...iv/cisloPeriodika	14
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Mráz, Marek Pospíšilová, Šárka Mayer, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	214434
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/11:00056976
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	MYB; CLL; miR-155 host gene; B-CLL (en)
http://linked.open.../riv/klicoveSlovo	B-CLL MYB miR-155 host gene CLL
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[19D581A2C781]
http://linked.open...i/riv/nazevZdroje	Blood
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	18 (xsd:int)
http://linked.open...vavai/riv/projekt	High throughput analysis of chromatin structure for development of novel diagnostic and therapeutic approaches in cancer. Investigation of pathophysiology of human leukemias/lymphomas during manipulation of oncogenic microRNAs. *Development of kit for testing molecular effects of anti-tumor drugs on chromatin structure Center for Experimental Hematology Functional and structural changes of microRNAs in lymphoproliferative malignancies and their impact on prognosis and prediction of therapy response
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	117
http://linked.open...iv/tvurceVysledku	Kulvait, Vojtěch Mayer, Jiří Mráz, Marek Nečas, Emanuel Pospíšilová, Šárka Pospíšil, Vít Stopka, Tomáš Trněný, Marek Vargová, Karin Zavadil, Jiří Kokavec, Juraj Bašová, Petra Berková, Adéla Burda, Pavel Curik, Nikola Karban, Josef Obrtlíková, Petra Savvulidi, Filipp
http://linked.open...ain/vavai/riv/wos	000289265500017
http://linked.open...n/vavai/riv/zamer	Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů Molekulárně biologické, genetické a epigenetické aspekty vzniku a rozvoje modelových tumorů dospělého věku. Význam pro epidemiologii, časnou diagnostiku a léčbu
issn	0006-4971
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1182/blood-2010-05-285064
http://localhost/t...ganizacniJednotka	14740
is http://linked.open...avai/riv/vysledek of	MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia

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