About: Distinct patterns of histone methylation and acetylation in human interphase nuclei

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	To study 3D nuclear distributions of epigenetic histone modifications such as H3(K9) acetylation, H3(K4) dimethylation, H3(K9) dimethylation, and H3(K27) trimethylation, and of histone methyl transferase Suv39H1, we used advanced image analysis methods, combined with Nipkow disk confocal microscopy. Total fluorescence intensity and distributions of fluorescently labelled proteins were analysed in formaldehyde-fixed interphase nuclei. Our data showed reduced fluorescent signals of H3(K9) acetylation and H3(K4) dimethylation (dime) at the nuclear periphery, while di-meH3(K9) was also abundant in chromatin regions closely associated with the nuclear envelope. Little overlapping (intermingling) was observed for di-meH3(K4) and H3(K27) trimethylation (tri-me), and for di-meH3(K9) and Suv39H1. To study 3D nuclear distributions of epigenetic histone modifications such as H3(K9) acetylation, H3(K4) dimethylation, H3(K9) dimethylation, and H3(K27) trimethylation, and of histone methyl transferase Suv39H1, we used advanced image analysis methods, combined with Nipkow disk confocal microscopy. Total fluorescence intensity and distributions of fluorescently labelled proteins were analysed in formaldehyde-fixed interphase nuclei. Our data showed reduced fluorescent signals of H3(K9) acetylation and H3(K4) dimethylation (dime) at the nuclear periphery, while di-meH3(K9) was also abundant in chromatin regions closely associated with the nuclear envelope. Little overlapping (intermingling) was observed for di-meH3(K4) and H3(K27) trimethylation (tri-me), and for di-meH3(K9) and Suv39H1. (en)
Title	Distinct patterns of histone methylation and acetylation in human interphase nuclei Distinct patterns of histone methylation and acetylation in human interphase nuclei (en)
skos:prefLabel	Distinct patterns of histone methylation and acetylation in human interphase nuclei Distinct patterns of histone methylation and acetylation in human interphase nuclei (en)
skos:notation	RIV/00216224:14330/07:00020185!RIV10-GA0-14330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/06/0978), P(GP202/03/D033), P(LC535), Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM0021622419)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Ulman, Vladimír Kozubek, Michal Bártová, Eva Kozubek, Stanislav Svoboda, David Matula, Petr Harničarová Horáková, Andrea Skalníková, Magdalena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	417591
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/07:00020185
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Histone methylation; acetylation; X chromosome; centromere; image analysis (en)
http://linked.open.../riv/klicoveSlovo	X chromosome image analysis acetylation centromere Histone methylation
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[C8953F712645]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Chromosome dynamics and organization during the cell cycle in normal and pathologic conditions Postranslational modifications of histones after cell treatment by inhibitors of histone deacetylases and during induction of cell differentiation The efect of methylation and acetylation on chromatin structure
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	56
http://linked.open...iv/tvurceVysledku	Bártová, Eva Kozubek, Stanislav Svoboda, David Ulman, Vladimír Kozubek, Michal Matula, Petr Harničarová, Andrea Skalníková, Magdalena
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Highly Parallel and Distributed Computing Systems
issn	0862-8408
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	14330
is http://linked.open...avai/riv/vysledek of	Distinct patterns of histone methylation and acetylation in human interphase nuclei Distinct patterns of histone methylation and acetylation in human interphase nuclei Distinct patterns of histone methylation and acetylation in human interphase nuclei

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