About: The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling.

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About: The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Wnt Planar Cell Polarity (PCP) signaling is a universal regulator of polarity in epithelial cells, but it regulates axon outgrowth in neurons, suggesting the existence of axonal modulators of Wnt-PCP activity. The Amyloid precursor proteins (APPs) are intensely investigated because of their link to Alzheimer's disease (AD). APP's in vivo function in the brain and the mechanisms underlying it remain unclear and controversial. Drosophila possesses a single APP homologue called APP Like, or APPL. APPL is expressed in all neurons throughout development, but has no established function in neuronal development. We therefore investigated the role of Drosophila APPL during brain development. We find that APPL is involved in the development of the Mushroom Body alfa beta neurons and, in particular, is required cell-autonomously for the beta-axons and non-cell autonomously for the alfa-axons growth. Wnt Planar Cell Polarity (PCP) signaling is a universal regulator of polarity in epithelial cells, but it regulates axon outgrowth in neurons, suggesting the existence of axonal modulators of Wnt-PCP activity. The Amyloid precursor proteins (APPs) are intensely investigated because of their link to Alzheimer's disease (AD). APP's in vivo function in the brain and the mechanisms underlying it remain unclear and controversial. Drosophila possesses a single APP homologue called APP Like, or APPL. APPL is expressed in all neurons throughout development, but has no established function in neuronal development. We therefore investigated the role of Drosophila APPL during brain development. We find that APPL is involved in the development of the Mushroom Body alfa beta neurons and, in particular, is required cell-autonomously for the beta-axons and non-cell autonomously for the alfa-axons growth. (en)
Title	The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling. The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling. (en)
skos:prefLabel	The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling. The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling. (en)
skos:notation	RIV/00216224:14310/13:00067038!RIV14-MSM-14310___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(GA204/09/0498), P(GAP301/11/0747), S, Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	11(5)
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Bryja, Vítězslav Janovská, Pavlína Tmejová, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	70605
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/13:00067038
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	PLANAR CELL POLARITY; ALZHEIMERS-DISEASE; AXONAL-TRANSPORT; FAMILY-MEMBERS; DEFICIENT MICE; GENE; APP; HYPOTHESIS; NEURON; THERAPEUTICS (en)
http://linked.open.../riv/klicoveSlovo	GENE ALZHEIMERS-DISEASE APP AXONAL-TRANSPORT DEFICIENT MICE FAMILY-MEMBERS HYPOTHESIS NEURON PLANAR CELL POLARITY THERAPEUTICS
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[F32CDE1BA6DD]
http://linked.open...i/riv/nazevZdroje	PLoS Biology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Dynamics of proteins interacting with Dishevelled and their importance for Wnt signalling Molecular mechanisms of non-canonical Wnt signaling in leukemia
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	2013
http://linked.open...iv/tvurceVysledku	Bryja, Vítězslav Tmejová, Kateřina Atak, Zeynep Kalender Claeys, Annelies De Strooper, Bart Dura, Jean-Maurice Hassan, Bassem A. Janovská, Pavlína Okray, Zeynep Reynaud, Elodie Soldano, Alessia Yan, Jiekun
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	1544-9173
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1371/journal.pbio.1001562
http://localhost/t...ganizacniJednotka	14310

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