About: Negative regulation of Wnt signaling mediated by CK1- phosphorylated Dishevelled via Ror2

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Dishevelled (Dvl) is a multifunctional effector of different Wnt cascades. We provide evidence that Dvl phosphorylated by casein kinase 1 epsilon can bind atypical receptor kinase Ror2. We show that CK1-phosphorylated Dvl induced by both canonical and non-canonical Wnt ligands triggers negative feedback regulation in a Ror2-dependent manner. Dishevelled (Dvl) is a multifunctional effector of different Wnt cascades. We provide evidence that Dvl phosphorylated by casein kinase 1 epsilon can bind atypical receptor kinase Ror2. We show that CK1-phosphorylated Dvl induced by both canonical and non-canonical Wnt ligands triggers negative feedback regulation in a Ror2-dependent manner. (en)
Title	Negative regulation of Wnt signaling mediated by CK1- phosphorylated Dishevelled via Ror2 Negative regulation of Wnt signaling mediated by CK1- phosphorylated Dishevelled via Ror2 (en)
skos:prefLabel	Negative regulation of Wnt signaling mediated by CK1- phosphorylated Dishevelled via Ror2 Negative regulation of Wnt signaling mediated by CK1- phosphorylated Dishevelled via Ror2 (en)
skos:notation	RIV/00216224:14310/10:00049637!RIV12-GA0-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/09/0498), P(GC204/09/J030), P(GD204/09/H058), Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Mašek, Jan Bernatík, Ondřej Bryja, Vítězslav Krejčí, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	274158
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/10:00049637
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Wnt/beta-catenin signaling; casein kinase; Ror2 (en)
http://linked.open.../riv/klicoveSlovo	Ror2 Wnt/beta-catenin signaling casein kinase
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[96A374D5BF49]
http://linked.open...i/riv/nazevZdroje	FASEB JOURNAL
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Intercellular signalling in development and disease The role of beta-arrestin in achieving Wnt-signaling specificity Dynamics of proteins interacting with Dishevelled and their importance for Wnt signalling
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	24
http://linked.open...iv/tvurceVysledku	Bryja, Vítězslav Krejčí, Pavel Mašek, Jan Mundlos, Stefan Bernatík, Ondřej Kirchner, Katharina Mahl, Annika Schambony, Alexandra Stricker, Sigmar Witte, Florian
http://linked.open...ain/vavai/riv/wos	000279343600028
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	0892-6638
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1096/fj.09-150615
http://localhost/t...ganizacniJednotka	14310
is http://linked.open...avai/riv/vysledek of	Negative regulation of Wnt signaling mediated by CK1- phosphorylated Dishevelled via Ror2 Negative regulation of Wnt signaling mediated by CK1- phosphorylated Dishevelled via Ror2

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