About: Computational Tools for Designing and Engineering Biocatalysts.

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Computational Tools for Designing and Engineering Biocatalysts. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Current computational tools to assist experimentalists for the design and engineering of proteins with desired catalytic properties are reviewed. The applications of these tools for de novo design of protein active sites, optimization of substrate access and product exit pathways, redesign of protein protein interfaces, identification of neutral/advantageous/deleterious mutations in the libraries from directed evolution and stabilization of protein structures are described. Remarkable progress is seen in de novo design of enzymes catalyzing a chemical reaction for which a natural biocatalyst does not exist. Yet, constructed biocatalysts do not match natural enzymes in their efficiency, suggesting that more research is needed to capture all the important features of natural biocatalysts in theoretical designs. Current computational tools to assist experimentalists for the design and engineering of proteins with desired catalytic properties are reviewed. The applications of these tools for de novo design of protein active sites, optimization of substrate access and product exit pathways, redesign of protein protein interfaces, identification of neutral/advantageous/deleterious mutations in the libraries from directed evolution and stabilization of protein structures are described. Remarkable progress is seen in de novo design of enzymes catalyzing a chemical reaction for which a natural biocatalyst does not exist. Yet, constructed biocatalysts do not match natural enzymes in their efficiency, suggesting that more research is needed to capture all the important features of natural biocatalysts in theoretical designs. (en)
Title	Computational Tools for Designing and Engineering Biocatalysts. Computational Tools for Designing and Engineering Biocatalysts. (en)
skos:prefLabel	Computational Tools for Designing and Engineering Biocatalysts. Computational Tools for Designing and Engineering Biocatalysts. (en)
skos:notation	RIV/00216224:14310/09:00029428!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA201/07/0927), P(GA203/08/0114), P(LC06010), Z(MSM0021622412), Z(MSM0021622413)
http://linked.open...iv/cisloPeriodika	13
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Damborský, Jiří Brezovský, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	307959
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/09:00029428
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	protein; engineering; biocatalysts (en)
http://linked.open.../riv/klicoveSlovo	engineering protein biocatalysts
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[11ACF1F4BBE8]
http://linked.open...i/riv/nazevZdroje	CURRENT OPINION IN BIOLOGICAL CHEMISTRY
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Specific ion effects for proteins in solutions and related biologically relevant systems. Center of Biocatalysis and Biotransformation Visualization of protein structures
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	1
http://linked.open...iv/tvurceVysledku	Brezovský, Jan Damborský, Jiří
http://linked.open...ain/vavai/riv/wos	000266192400005
http://linked.open...n/vavai/riv/zamer	Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL) Proteiny v metabolismu a při interakci organismů s prostředím
issn	1367-5931
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	14310
is http://linked.open...avai/riv/vysledek of	Computational Tools for Designing and Engineering Biocatalysts. Computational Tools for Designing and Engineering Biocatalysts. Computational Tools for Designing and Engineering Biocatalysts. Computational Tools for Designing and Engineering Biocatalysts.

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 47 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software