About: The Extracellular Domain of Lrp5/6 Inhibits Non-Canonical Wnt Signaling in vivo.

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About: The Extracellular Domain of Lrp5/6 Inhibits Non-Canonical Wnt Signaling in vivo. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Lrp5/6 are crucial coreceptors for Wnt/beta-catenin signaling, a pathway biochemically distinct from noncanonical Wnt signaling pathways. Here, we examined the possible participation of Lrp5/6 in noncanonical Wnt signaling using biochemical approach, and mouse and Xenopus in vivo models. We provide evidence that the extracellular domains of Lrp5/6 behave as physiologically relevant inhibitors of noncanonical Wnt signaling during Xenopus and mouse development in vivo. Lrp5/6 are crucial coreceptors for Wnt/beta-catenin signaling, a pathway biochemically distinct from noncanonical Wnt signaling pathways. Here, we examined the possible participation of Lrp5/6 in noncanonical Wnt signaling using biochemical approach, and mouse and Xenopus in vivo models. We provide evidence that the extracellular domains of Lrp5/6 behave as physiologically relevant inhibitors of noncanonical Wnt signaling during Xenopus and mouse development in vivo. (en)
Title	The Extracellular Domain of Lrp5/6 Inhibits Non-Canonical Wnt Signaling in vivo. The Extracellular Domain of Lrp5/6 Inhibits Non-Canonical Wnt Signaling in vivo. (en)
skos:prefLabel	The Extracellular Domain of Lrp5/6 Inhibits Non-Canonical Wnt Signaling in vivo. The Extracellular Domain of Lrp5/6 Inhibits Non-Canonical Wnt Signaling in vivo. (en)
skos:notation	RIV/00216224:14310/08:00024446!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Bryja, Vítězslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	367478
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/08:00024446
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	non-canonical Wnt signalling; Lrp5/6; mouse; Xenopus (en)
http://linked.open.../riv/klicoveSlovo	Xenopus mouse Lrp5/6 non-canonical Wnt signalling
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[2BA557A07536]
http://linked.open...i/riv/nazevZdroje	: Molecular Biology of the Cell
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	20
http://linked.open...iv/tvurceVysledku	Bryja, Vítězslav Andersson, Emma R. Arenas, Ernest Čajánek, Lukáš Bryjová, Lenka Schambony, Alexandra Biris, Kristin K. Buckingham, Margaret Esner, Milan Hall, Anita C. Kraft, Bianca Yamaguchi, Terry P.
http://linked.open...ain/vavai/riv/wos	000263031900017
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	1059-1524
number of pages	13 (xsd:int)
http://localhost/t...ganizacniJednotka	14310
is http://linked.open...avai/riv/vysledek of	The Extracellular Domain of Lrp5/6 Inhibits Non-Canonical Wnt Signaling in vivo. The Extracellular Domain of Lrp5/6 Inhibits Non-Canonical Wnt Signaling in vivo. The Extracellular Domain of Lrp5/6 Inhibits Non-Canonical Wnt Signaling in vivo. The Extracellular Domain of Lrp5/6 Inhibits Non-Canonical Wnt Signaling in vivo.

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