About: Incidence of cytogenetic aberrations in two B lineage subpopulations in multiple myeloma patients analyzed by combination of whole-genome profiling and FISH

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About: Incidence of cytogenetic aberrations in two B lineage subpopulations in multiple myeloma patients analyzed by combination of whole-genome profiling and FISH Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Multiple myeloma (MM) is an incurable malignant disease of the terminal developmental stage of B-lymphocytes. While genetic heterogeneity of MM is widely described, little is known about its genetic basis as well as primary damage during plasma cells (PC) development. In this study, we focused on genome-wide screening of DNA copy number changes using oligonucleotide-based array-CGH together with I-FISH of the IgH locus rearrangements in pair samples of bone marrow B-cells (CD19+) and CD138+ PC from newly diagnosed MM patients. The IgH disruption was found in 8.9% (4/45) of CD19+ samples and in 57.8% (26/45) of CD138+ samples. The genomic profiling using array-CGH identified copy number alterations (CNAs) in 10% (2/20) of CD19+ samples in regions known to be important for MM pathogenesis. In contrast, we found CNAs in 100% (16/16) of CD138+ samples. Multiple myeloma (MM) is an incurable malignant disease of the terminal developmental stage of B-lymphocytes. While genetic heterogeneity of MM is widely described, little is known about its genetic basis as well as primary damage during plasma cells (PC) development. In this study, we focused on genome-wide screening of DNA copy number changes using oligonucleotide-based array-CGH together with I-FISH of the IgH locus rearrangements in pair samples of bone marrow B-cells (CD19+) and CD138+ PC from newly diagnosed MM patients. The IgH disruption was found in 8.9% (4/45) of CD19+ samples and in 57.8% (26/45) of CD138+ samples. The genomic profiling using array-CGH identified copy number alterations (CNAs) in 10% (2/20) of CD19+ samples in regions known to be important for MM pathogenesis. In contrast, we found CNAs in 100% (16/16) of CD138+ samples. (en)
Title	Incidence of cytogenetic aberrations in two B lineage subpopulations in multiple myeloma patients analyzed by combination of whole-genome profiling and FISH Incidence of cytogenetic aberrations in two B lineage subpopulations in multiple myeloma patients analyzed by combination of whole-genome profiling and FISH (en)
skos:prefLabel	Incidence of cytogenetic aberrations in two B lineage subpopulations in multiple myeloma patients analyzed by combination of whole-genome profiling and FISH Incidence of cytogenetic aberrations in two B lineage subpopulations in multiple myeloma patients analyzed by combination of whole-genome profiling and FISH (en)
skos:notation	RIV/00216224:14110/14:00073433!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP304/10/1395), P(NS10207), P(NT11154), P(NT13190), P(NT13492), Z(MSM0021622434)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Kryukov, Fedor Smetana, Jan Dementyeva, Elena Vladimirovna Kuglík, Petr Ihnatová, Ivana Hájek, Roman Němec, Pavel Mikulášová, Aneta Grešliková, Henrieta Kupská, Renata
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	21116
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/14:00073433
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	multiple myeloma; CD19+; CD138+; cytogenetics; array-CGH; FISH (en)
http://linked.open.../riv/klicoveSlovo	CD138+ FISH multiple myeloma CD19+ array-CGH cytogenetics
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[B71A4E0B141E]
http://linked.open...i/riv/nazevZdroje	Neoplasma
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	10 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of chromosome 1 abnormalities and NF-kappaB cascade in patogenesis of multiple myeloma The role of B cell lineage mitotic disruptions in multiple myeloma Analysis of Clonal Plasma Cells Progenitors in Monoclonal Gammopathies Molecular signature of centrosome abnormalities and their clinical impact for patients with multiple myeloma Role of genetic abnormalities in development and progression of precancerosis monoclonal gammopathy of undetermined significance
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	61
http://linked.open...iv/tvurceVysledku	Hájek, Roman Kuglík, Petr Kryukov, Fedor Smetana, Jan Němec, Pavel Mikulášová, Aneta Grešliková, Henrieta Kupská, Renata Kryukova, Elena Vladimirovna Ihnatová, Ivana
http://linked.open...ain/vavai/riv/wos	000329769500007
http://linked.open...n/vavai/riv/zamer	From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies
issn	0028-2685
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.4149/neo_2014_008
http://localhost/t...ganizacniJednotka	14110

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