About: Analysis of Clonal Plasma Cells Progenitors in Monoclonal Gammopathies

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rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=GAP304/10/1395
Description	Detailed study of heterogeneous subpopulations of myeloma cells and their precursors/progenitors in monoclonal gammopathy patients can lead to identification and characterisation of myeloma stem cells. Using polychromatic flow cytometry with sorting of cells, phenotype of myeloma stem cells can be detected and different subpopulation can be selected for clonality assessment. In vitro culturing then can prove self renewal capacity of these myeloma stem cells and their multidrug resistance as well. We suppose that using these approaches we are able to obtain new information in area of pathophysiology of myeloma cells and their behaviour, which can be potentially used for determination of predictive factors applicable in progression of monoclonal gammopaty of undetermined significance to multiple myeloma. (en) Podrobné studium heterogenních subpopulací myelomových buněk a jejich prekurzorů/progenitorů u pacientů s monoklonálními gamapatiemi může napomoci nalezení a charakterizaci myelomových kmenových buněk. Využití polychromatické průtokové cytometrie buněk může vést k odhalení fenotypu myelomových kmenových buněk, tyto mohou být následně purifikovány a jejich klonalita prověřena na molekulární úrovni. In vitro kultivace mohou u těchto myelomových kmenových buněk prokázat jejich sebeobnovovací potenciál a také rezistenci na léčiva. Využitím zmiňovaných postupů bychom mohli získat nové informace v oblasti patofyziologie myelomových buněk a jejich chování, čehož může být nasledně využito k identifikaci prediktivních faktorů uplatnitelných u progrese monoklonální gamapatie nejasného významu do mnohočetného myelomu.
Title	Analysis of Clonal Plasma Cells Progenitors in Monoclonal Gammopathies (en) Analýza klonálních progenitorů plazmatických buněk u monoklonálních gamapatií
skos:notation	GAP304/10/1395
http://linked.open...avai/cep/aktivita	Standard projects
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http://linked.open...datumDodatniDoRIV	2015-04-23 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	100784600
http://linked.open...ai/cep/hlavniObor	FD - Onkologie a hematologie
http://linked.open...vai/cep/kategorie	ZV - Základní výzkum
http://linked.open.../cep/klicovaSlova	monoclonal gammopathy plasma cell myeloma stem cells flow cytometry (en)
http://linked.open...ep/partnetrHlavni	Lékařská fakulta
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http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/P304-10-1395
http://linked.open...iciPoslednihoRoku	2015
http://linked.open...atUdajeProjZameru	2015
http://linked.open.../vavai/cep/soutez	SGA02010GA-ST
http://linked.open...usZobrazovaneFaze	DRRVK
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2015-12-31 (xsd:date)
http://linked.open.../cep/vedlejsiObor	EB - Genetika a molekulární biologie
http://linked.open...ep/zahajeniReseni	2010-01-01 (xsd:date)
http://linked.open...tniCyklusProjektu	ZBBKPK
is http://linked.open...vavai/riv/projekt of	Improved IgH-based MRD Detection By Using Droplet Digital PCR: a Comparison With Real Time Quantitative PCR in MCL and MM Úloha chromozomových aberací v patogenezi monoklonální gamapatie nejasného významu Biology of Immune Regulation in Multiple Myeloma : Evaluation of immune regulatory cells and their clinical significance in patients with multiple myeloma Contribution of regulatory T cells to immunosuppression and disease progression in multiple myeloma patients Proteasome Inhibitors in Treatment of Multiple Myeloma Myeloma stem cell concepts, heterogeneity and plasticity of multiple myeloma Serum miR-29a as a Marker of Multiple Myeloma Association of aneuploidy category with centrosome amplification in multiple myeloma Flow Cytometry in Monoclonal Gammopathies Flow Cytometric Phenotyping and Analysis of T Regulatory Cells in Multiple Myeloma Patients Genomics in Multiple Myeloma Research Multiple Myeloma Monoclonal Gammopathy of Undeterminated Significance: Introduction and Current Clinical Issues Oligonucleotide-based Array CGH as a Diagnostic Tool in Multiple Myeloma Patients Sample Processing and Methodological Pitfalls in Multiple Myeloma Research Stem cell marker nestin is expressed in plasma cells of multiple myeloma patients Bone marrow plasma cell separation - validation of separation algorithm Incidence of cytogenetic aberrations in two B lineage subpopulations in multiple myeloma patients analyzed by combination of whole-genome profiling and FISH MicrRNA in oncology Mechanism of immunomodulatory drugs in multiple myeloma Clinical implication of centrosome amplification and expression of centrosomal functional genes in multiple myeloma Complete remission of multiple myeloma associated scleredema after bortezomib-based treatment Cell cycle genes co-expression in multiple myeloma and plasma cell leukemia Cladribine (2-chlorodeoxyadenosine) in frontline chemotherapy for adult Langerhans cell histiocytosis: A single-center study of seven cases Visualization of Numerical Centrosomal Abnormalities by Immunofluorescent Staining Analýza moderních prognostických faktorů na buněčné a molekulární úrovni určujících riziko transformace monoklonální gamapatie nejasného významu do mnohočetného myelomu Prognostic significance of morphology in multiple myeloma Algoritmus separace plazmatických buněk ze vzorků kostní dřeně Functionally suppressive CD8 T regulatory cells are increased in patients with multiple myeloma: a cause for immune impairment Induction by lenalidomide and dexamethasone combination increases regulatory cells of patients with previously untreated multiple myeloma Increased T regulatory cells are associated with adverse clinical features and predict progression in multiple myeloma. Molekulární podstata Waldenströmovy makroglobulinemie Comparative Plasma Proteomic Analysis of Patients with Multiple Myeloma Treated with Bortezomib-based Regimens Molecular heterogeneity and centrosome-associated genes in multiple myeloma 5th Myeloma workshop: Flow cytometry and cytogenetics: Application of flow cytometry and cytogenetics approach in monoclonal gammopathies and multiple myeloma Optimization of immunomagnetic selection of myeloma cells from bone marrow using magnetic activated cell sorting Review of phenotypic markers used in flow cytometric analysis of MGUS and MM, and applicability of flow cytometry in other plasma cell disorders Obecná onkologie Polymorphisms Contribution to the Determination of Significant Risk of Specific Toxicities in Multiple Myeloma Prognostický význam imunofenotypizace u nemocných s monoklonální gamapatií nejasného významu a mnohočetným myelomem Prognostic significance of morphological assessment of plasma cells in multiple myeloma. Regulatory Cells and Multiple Myeloma Význam mikroprostředí kostní dřeně v patogenezi mnohočetného myelomu Impact of Nestin Analysis in Multiple Myeloma Gain(1)(q21) is an Unfavorable Genetic Prognostic Factor for Patients With Relapsed Multiple Myeloma Treated With Thalidomide but Not for Those Treated With Bortezomib Heterogeneity and Plasticity of Multiple Myeloma Flow Cytometry-Based Enumeration and Functional Characterization of CD8 T Regulatory Cells in Patients with Multiple Myeloma Before and After Lenalidomide Plus Dexamethasone Treatment Nestin expression throughout multistep pathogenesis of multiple myeloma
is http://linked.open...vavai/cep/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/GAP304%2F10%2F1395/2010/orjk%3A14110 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/GAP304%2F10%2F1395/2011/orjk%3A14110 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/GAP304%2F10%2F1395/2012/orjk%3A14110 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/GAP304%2F10%2F1395/2013/orjk%3A14110 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/GAP304%2F10%2F1395/2014/orjk%3A14110 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/GAP304%2F10%2F1395/2015/orjk%3A14110

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