About: Clinical implication of centrosome amplification and expression of centrosomal functional genes in multiple myeloma

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About: Clinical implication of centrosome amplification and expression of centrosomal functional genes in multiple myeloma Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Background: Multiple myeloma (MM) is a low proliferative tumor of postgerminal center plasma cell (PC). Centrosome amplification (CA) is supposed to be one of the mechanisms leading to chromosomal instability. Also, CA is associated with deregulation of cell cycle, mitosis, DNA repair and proliferation. The aim of our study was to evaluate the prognostic significance and possible role of CA in pathogenesis and analysis of mitotic genes as mitotic disruption markers. Design and methods: A total of 173 patients were evaluated for this study. CD138+ cells were separated by MACS. Immunofluorescent labeling of centrin was used for evaluation of centrosome amplification in PCs. Interphase FISH with cytoplasmic immunoglobulin light chain staining (cIg FISH) and qRT-PCR were performed on PCs. Results: Based on the immunofluorescent staining results, all patients were divided into two groups: CA positive (38.2%) and CA negative (61.8%). Background: Multiple myeloma (MM) is a low proliferative tumor of postgerminal center plasma cell (PC). Centrosome amplification (CA) is supposed to be one of the mechanisms leading to chromosomal instability. Also, CA is associated with deregulation of cell cycle, mitosis, DNA repair and proliferation. The aim of our study was to evaluate the prognostic significance and possible role of CA in pathogenesis and analysis of mitotic genes as mitotic disruption markers. Design and methods: A total of 173 patients were evaluated for this study. CD138+ cells were separated by MACS. Immunofluorescent labeling of centrin was used for evaluation of centrosome amplification in PCs. Interphase FISH with cytoplasmic immunoglobulin light chain staining (cIg FISH) and qRT-PCR were performed on PCs. Results: Based on the immunofluorescent staining results, all patients were divided into two groups: CA positive (38.2%) and CA negative (61.8%). (en)
Title	Clinical implication of centrosome amplification and expression of centrosomal functional genes in multiple myeloma Clinical implication of centrosome amplification and expression of centrosomal functional genes in multiple myeloma (en)
skos:prefLabel	Clinical implication of centrosome amplification and expression of centrosomal functional genes in multiple myeloma Clinical implication of centrosome amplification and expression of centrosomal functional genes in multiple myeloma (en)
skos:notation	RIV/00216224:14110/13:00065607!RIV14-MZ0-14110___
http://linked.open...avai/predkladatel	Lékařská fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GAP304/10/1395), P(NS10207), P(NT11154), P(NT13190)
http://linked.open...iv/cisloPeriodika	77
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Kryukov, Fedor Ševčíková, Sabina Kuglík, Petr Ihnatová, Ivana Jarkovský, Jiří Hájek, Roman Němec, Pavel Kubiczková, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	65696
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/13:00065607
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Multiple myeloma; Centrosome amplification; Overall survival (en)
http://linked.open.../riv/klicoveSlovo	Centrosome amplification Overall survival Multiple myeloma
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[0108BB49CCCC]
http://linked.open...i/riv/nazevZdroje	Journal of Translational Medicine
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of chromosome 1 abnormalities and NF-kappaB cascade in patogenesis of multiple myeloma The role of B cell lineage mitotic disruptions in multiple myeloma Analysis of Clonal Plasma Cells Progenitors in Monoclonal Gammopathies Molecular signature of centrosome abnormalities and their clinical impact for patients with multiple myeloma
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	11
http://linked.open...iv/tvurceVysledku	Hájek, Roman Jarkovský, Jiří Kuglík, Petr Kryukov, Fedor Ševčíková, Sabina Němec, Pavel Kubiczková, Lenka Dementyeva, Elena Ihnatová, Ivana Minarik, Jiří Stefanikova, Zdena
http://linked.open...ain/vavai/riv/wos	000317292200001
issn	1479-5876
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1186/1479-5876-11-77
http://localhost/t...ganizacniJednotka	14110

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