About: Interaction of late apoptotic and necrotic cells with Vitronectin

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1371/journal.pone.0019243
Description	Vitronectin (Vn) is an abundant plasma glycoprotein identified also as a part of extracellular matrix. Vn is substantially enriched at sites of injured, fibrosing, inflamed, and tumor tissues where it is believed to be involved in wound healing and tissue remodeling. Little is known about the mechanism of Vn localization into the damaged tissues. 2E12 antibody has been described to bind a subset of late apoptotic cells. The antigen recognized by 2E12 antibody was identified as Vn. Vn binds to the late apoptotic and necrotic cells in cell cultures in vitro as well as in murine thymus and spleen in vivo. Confocal microscopy revealed that Vn binds to an intracellular cytoplasmic structure after the membrane rupture. Vitronectin could serve as a marker of membrane disruption in necrosis and apoptosis for flow cytometry analysis. Vn binding to dead cells may represent one of the mechanisms of Vn incorporation into the injured tissues. Vitronectin (Vn) is an abundant plasma glycoprotein identified also as a part of extracellular matrix. Vn is substantially enriched at sites of injured, fibrosing, inflamed, and tumor tissues where it is believed to be involved in wound healing and tissue remodeling. Little is known about the mechanism of Vn localization into the damaged tissues. 2E12 antibody has been described to bind a subset of late apoptotic cells. The antigen recognized by 2E12 antibody was identified as Vn. Vn binds to the late apoptotic and necrotic cells in cell cultures in vitro as well as in murine thymus and spleen in vivo. Confocal microscopy revealed that Vn binds to an intracellular cytoplasmic structure after the membrane rupture. Vitronectin could serve as a marker of membrane disruption in necrosis and apoptosis for flow cytometry analysis. Vn binding to dead cells may represent one of the mechanisms of Vn incorporation into the injured tissues. (en)
Title	Interaction of late apoptotic and necrotic cells with Vitronectin Interaction of late apoptotic and necrotic cells with Vitronectin (en)
skos:prefLabel	Interaction of late apoptotic and necrotic cells with Vitronectin Interaction of late apoptotic and necrotic cells with Vitronectin (en)
skos:notation	RIV/00023736:_____/11:00009193!RIV12-MZ0-00023736
http://linked.open...avai/predkladatel	Ústav hematologie a krevní transfúze
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0506), Z(AV0Z50200510), Z(AV0Z50520514), Z(MZ0UHKT2005)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Stöckbauer, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	205238
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/11:00009193
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	apoptosis; vitronectin; necrosis (en)
http://linked.open.../riv/klicoveSlovo	vitronectin necrosis apoptosis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[EC3805882F85]
http://linked.open...i/riv/nazevZdroje	PLoS One
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Molecular and Cellular Immunology
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	6
http://linked.open...iv/tvurceVysledku	Stöckbauer, Petr Angelisová, P. Brdička, T. Horváth, O. Hořejší, V. Man, P. Špička, I. Štěpánek, O.
http://linked.open...ain/vavai/riv/wos	000290224800019
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů Význam molekulárně biologických vyšetření pro objasnění patogeneze a pro diagnostiku poruch krvetvorby a využití krvetvorné buňky v léčbě onemocnění krvetvorby a jiných tkání.
issn	1932-6203
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1371/journal.pone.0019243
is http://linked.open...avai/riv/vysledek of	Interaction of late apoptotic and necrotic cells with Vitronectin Interaction of late apoptotic and necrotic cells with Vitronectin

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