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  • To create the new “tailor-made” medicine of the 21st century it is necessary to analyze differences in genomes of individuals and obtain information on gene expression under various conditions. To reach this goal new methods for DNA and protein analysis have to be developed. It is believed that electrochemical methods can be particularly useful in inexpensive, delocalized parallel DNA analysis. Both the US and Czech groups are among the world leading laboratories in the development of electrochemical DNA sensors. It is expected that their collaboration will result in development of new DNA biotechnologies as well methods of electrochemical protein analysis important for biomedicine. Particular attention will be paid to interfacial properties of proteins playing their roles in cancer and in some neurodegenerative diseases, such as Parkinson´s and Alzheimer´s diseases. (en)
  • Cíle projektu zahrnují především základní výzkum vzájemných interakcí bílkovin a nukleových kyselin a interakcí těchto látek s povrchy a zvláště s elektrodami.
Title
  • Interactions of proteins and nucleic acids with surfaces. New tools for biomedicine (en)
  • Interakce proteinů a nukleových kyselin s povrchy. Nové nástroje pro biomedicínu
skos:notation
  • ME09038
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  • DNA; proteins; electrochemistry; biotechnology; medicine (en)
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  • Elektrochemickým studiem nukleových kyselin, bílkovin a cukrů byly získány důležité poznatky mající uplatnění v biomedicíně, zejména ve výzkumu rakoviny. Ve spolupráci s americkou laboratoří jsme zkonstruovali čip pro detekci patogenů s potenciálním komerčním využitím. Výsledky projektu byly zveřejněné v 24 publikacích v mezinárodních impaktovaných časopisech. (cs)
  • Important findings in electrochemistry of nucleic acids, proteins and carbohydrates were made, with possible application in biomedicine, especially in cancer research. In cooperation with US laboratory, we have constructed a chip for pathogen detection with potential for commercialization. Results obtained within the project were published as 24 papers in international impacted journals. (en)
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  • DNA
  • biotechnology
  • electrochemistry
  • proteins
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