About: Native and denatured forms of proteins can be discriminated at edge plane carbon electrodes

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About: Native and denatured forms of proteins can be discriminated at edge plane carbon electrodes Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In an attempt to develop a label-free electrochemical method for detection of changes in protein structures based on oxidizability of tyrosine and tryptophan residues we tested different types of carbon electrodes. We found that using edge plane pyrolytic graphite electrode we can discriminate between native and denatured forms of human serum albumin and of other proteins. The electrochemical denaturation curve agreed reasonably well with that based on intrinsic fluorescence of tyrosine and tryptophan. It can be expected that the electrochemical method will be applicable to a large number of proteins and may become useful in biomedicine and proteomics. In an attempt to develop a label-free electrochemical method for detection of changes in protein structures based on oxidizability of tyrosine and tryptophan residues we tested different types of carbon electrodes. We found that using edge plane pyrolytic graphite electrode we can discriminate between native and denatured forms of human serum albumin and of other proteins. The electrochemical denaturation curve agreed reasonably well with that based on intrinsic fluorescence of tyrosine and tryptophan. It can be expected that the electrochemical method will be applicable to a large number of proteins and may become useful in biomedicine and proteomics. (en)
Title	Native and denatured forms of proteins can be discriminated at edge plane carbon electrodes Native and denatured forms of proteins can be discriminated at edge plane carbon electrodes (en)
skos:prefLabel	Native and denatured forms of proteins can be discriminated at edge plane carbon electrodes Native and denatured forms of proteins can be discriminated at edge plane carbon electrodes (en)
skos:notation	RIV/68081707:_____/12:00380149!RIV13-AV0-68081707
http://linked.open...avai/predkladatel	Biofyzikální ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP301/11/2055), P(KJB100040901), P(ME09038), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	JUL
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Paleček, Emil Ostatná, Veronika Černocká, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	153179
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/12:00380149
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	protein denaturation; carbon electrodes; edge plane pyrolytic graphite (en)
http://linked.open.../riv/klicoveSlovo	carbon electrodes edge plane pyrolytic graphite protein denaturation
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[9D2D6EB54419]
http://linked.open...i/riv/nazevZdroje	Analytica Chimica Acta
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	New methods of analysis of proteins and their glycosylation in cancer - combination of electrochemistry, microfludic biosensors and mass spectrometry. Interfacial properties of alpha-synuclein and aggregation of this protein in Parkinson's disease Interactions of proteins and nucleic acids with surfaces. New tools for biomedicine
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	735
http://linked.open...iv/tvurceVysledku	Ostatná, Veronika Paleček, Emil Černocká, Hana Kurzatkowska, K.
http://linked.open...ain/vavai/riv/wos	000306150400004
http://linked.open...n/vavai/riv/zamer	Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0003-2670
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.aca.2012.05.012
is http://linked.open...avai/riv/vysledek of	Native and denatured forms of proteins can be discriminated at edge plane carbon electrodes

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