About: Study of interactions of biological macromolecules and nanolayers with a view to research of polymer microfluidic biosensors and therapeutic nanoparticles

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Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=KAN208240651
Description	Aim of the proposed project is a research of highly integrated microfluidic equipment (biosensors) based on the detection of biologically specific components from the sample using immobilized protein nanolayers and a research of organization of macromolecular nanostructures, protein nanolayers and retroviral capsids for diagnostic and therapeutics purposes. Partial aims of the project are: construction of proper microfluidic chips, formation of biologically active nanolayers and internal structures of chips, characterization of spatial and electric properties of immobilized nanolayers and polymer carriers, characterization of nanoparticles carrying therapeutic gene on the level of nanoscale, possible utilization of electrokinetic transport for sample dosing, testing of chips as sensors both on model and practically utilizable immunoanalytic systems, testing of parallel determination of various analytes and biosensors and optimization of structures of used proteins. (en) Cílem předkládaného projektu je výzkum vysoce integrovaných mikrofluidních zařízení (biosenzorů) založených na detekci biologicky specifických komponent ze vzorku pomocí imobilizovaných proteinových nanovrstev a výzkum organizace makromolekulárních nanostruktur, proteinových nanovrstev a retrovirových kapsid k diagnostickým a terapeutickým účelům. Dílčí cíle projektu jsou: zkonstruování vhodných mikrofluidních čipů, vytvoření biologicky aktivních nanovrstev ve vnitřních strukturách čipů, charakterizace prostorových a elektrických vlastnostní imobilizovaných nanovrstev a polymerních nosičů, charakterizace nanočástic nesoucích terapeutický gen na úrovni nanoměřítka, možné využití elektrokinetického transportu pro dávkování vzorku, testování čipů jako senzorů na různých modelových a prakticky využitelných imunoanalytických systémech, testování paralelního stanovení různých analytů na biosenzorech, optimalizace struktury použitých proteinů.
Title	Study of interactions of biological macromolecules and nanolayers with a view to research of polymer microfluidic biosensors and therapeutic nanoparticles (en) Studium interakcí biologických makromolekul a nanovrstev se zaměřením na výzkum polymerních mikrofluidních biosenzorů a terapeutických nanočástic
skos:notation	KAN208240651
http://linked.open...avai/cep/aktivita	Nanotechnologies for Society
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/KAN208240651/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/KAN208240651/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2011-04-22 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	82564962
http://linked.open...ai/cep/hlavniObor	CI - Průmyslová chemie a chemické inženýrství
http://linked.open...hodnoceniProjektu	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open...vai/cep/kategorie	ZV - Základní výzkum
http://linked.open.../cep/klicovaSlova	protein nano-layer; biosensor; microfluidic protein chip; immunoassay; antigen; antibody; nano-structured polymers; nano-macro interface; electrokinetic flow; Epstein-Barr virus; retrovirus; retroviral capsids; meso-scopic modeling (en)
http://linked.open...ep/partnetrHlavni	Vysoká škola chemicko-technologická v Praze
http://linked.open...inujicichPrijemcu	1 (xsd:int)
http://linked.open...cep/pocetPrijemcu	2 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open.../pocetVysledkuRIV	75 (xsd:int)
http://linked.open...enychVysledkuVRIV	75 (xsd:int)
http://linked.open...lneniVMinulemRoce	2010-03-09 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/KAN208240651
http://linked.open...iciPoslednihoRoku	2010
http://linked.open...atUdajeProjZameru	2011
http://linked.open.../vavai/cep/soutez	SAV02006-N
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2010-12-31 (xsd:date)
http://linked.open.../cep/vedlejsiObor	CE - Biochemie EC - Imunologie
http://linked.open...ep/zahajeniReseni	2006-07-01 (xsd:date)
http://linked.open...jektu+dodavatelem	Byly vytvořeny: LIF aparatura pro detekci biomarkerů, postupy výroby plastových mikročipů a protilátky proti virovým nanočásticím. Byly získány poznatky o ac elektrokinetických čerpadlech, transportních vlastnostech polymerů a struktuře virových částic. (cs) LIF device for biomarker detection, procedures of plastic microchip fabrication, and antibodies against viral nanoparticles were developed. Findings on electrokinetic pumps, transport properties of polymers and structure of viral particles were obtained. (en)
http://linked.open...tniCyklusProjektu	ZBBBKU
http://linked.open.../cep/klicoveSlovo	Epstein-Barr virus antibody antigen biosensor electrokinetic flow immunoassay microfluidic protein chip nano-macro interface nano-structured polymers retroviral capsids retrovirus protein nano-layer
is http://linked.open...vavai/riv/projekt of	Technical report - Production technology and applications of microfluidic chips from polydimethylsiloxane The impact of altered polyprotein ratios on the assembly and infectivity of Mason-Pfizer monkey virus. Analysis of the effect of faradaic currents on electroosmotic flow Anomalous diffusion of pentane in polystyrene AC electroosmotic micropumps Parametrical studies of electroosmotic transport characteristics in submicrometer channels Optical system for detection of bioaffinity complexes in microfluidic chips. Detection of bioaffinity complexes in microchannels by fluorescence techniques. Preparation of SERS-active substrates with large surface area for Raman spectral mapping and testing of their surface nanostructure Electroosmotic characteristics of polystyrene microchips - experiments and modeling Study of electroosmotic characteristics by current monitoring and fluorescence Numerical Models for AC Electro-osmotic AFM and SEM study of copper SERS-active substrates Characterization of SERS-active substrates by AFM Predictive modeling of ionic permselectivity of porous media Numerical Models for AC Electro-osmotic Micropumps Characterization of copper SERS-active substrates prepared by electrochemical deposition Numerical study on AC electroosmosis in microfluidic channels Metal electrodes in plastic microfluidic systems Study on surface properties of PDMS microfluidic chips treated with albumin Non-equilibrium modeling of AC electroosmosis in microfluidic channels - parametrical studies DEPENDENCE OF EFFECTIVE ZETA-POTENTIAL ON ELECTROLYTE CONCENTRATION COMPARISON OF SLIP AND NON-SLIP MATHEMATICAL MODELS OF AC ELECTROOSMOSIS IN MICROCHANNELS WITH COMPLEX ELECTRODE GEOMETRIES CHARACTERIZATION OF ELECTROOSMOTIC FLOW IN PDMS MICROFLUIDIC DEVICES Non-equilibrium modeling of AC electroosmosis in microfluidic channels - parametrical studies Diffusion in semi-crystalline polymers Diffusion in semi-crystalline polyolefins with lamellar and spherulitic morphology Dynamics of foaming of polystyrene particles Mathematical modeling of AC electroosmotic micropumps with asymmetric co-planar electrodes Immunoanalytical detection of bioaffinity complexes in PDMS microfluidic chips Development of technologies for fabrication of microfluidic systems Semi-crystalline polymers: Reconstruction of morphology and modeling of diffusion transport Characterization of hetero-phase polymers by TD-NMR Mapping of semi-crystalline structures of polyolefins by AFM and digital reconstruction of lamellae morphology Formation and separation of segmented flow in microfluidic chips Development of slug-flow microfluidic devices for lipase catalyzed reactions Mathematical modeling of AC electroosmosis in microuidic and nanouidic chips using equilibrium and non-equilibrium approaches Plastic microfluidic systems made by imprinting against an epoxy stamp PDMS microfluidic chips prepared by a novel casting and pre-polymerization method Toward High Net Velocities in AC Electroosmotic Micropumps Based on Asymmetric Coplanar Electrodes LIF microfluidic system for immunoanalytical detection Microfluidic device for AC electroosmotic fluid pumping Reconstruction of lamellae morphology of semi-crystalline polymers and modeling of diffusion transport Traveling-wave electroosmotic pumps driven by non-sinusoidal AC signals Fabrication of PDMS microfluidic devices Numerical Models for AC Electro-osmotic Micropumps Modeling of morphology evolution of high-impact polystyrene The effect of point mutations within the N-terminal domain of Mason-Pfizer monkey virus capsid protein on virus core assembly and infectivity Fast ferritin immunoassay on PDMS microchips Modelling of the high-impact polystyrene morphogenesis

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