About: Dynamics and Organization of Chromosomes in the Cell Cycle and during Differentiation under Normal and Pathological Conditions

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About: Dynamics and Organization of Chromosomes in the Cell Cycle and during Differentiation under Normal and Pathological Conditions Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

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rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=GBP302/12/G157
Description	The Project of Excellence represents a continuation of the successful Centre of Basic Research LC535 and will bring together the best Czech teams interested in the arrangement and function of the cell nucleus and epigenetics in normal and cancer cells either intact or damaged. We will accent the research of epigenetics and DNA damage in human pluripotent stem cells in relation to oncogenic transformation. Research in this field can provide highly important practical implications. Practical significance can be also expected from the research of complex chromosomal aberrations. Participation of computer scientists in the project will enable development of control software for microscope systems as well as high-level analysis of the results. Multidiciplinary nature of the consortium will enable the use of complementarity in methods and approaches, achieve synergistic effects, join elements of basic and applied research and solve difficult objectives. The joint research will generate a high added value leading to the growth of scientific excellence and of an international recognition. (en) Projekt excelence navazuje na podobně pojmenovaný úspěšný projekt Centra základního výzkumu LC535 a propojí nejlepší české týmy zabývající se uspořádáním a funkcí jádra buňky a epigenetikou buněk zdravých i nádorových, v normě i při poškození. Důraz bude kladen na výzkum epigenetiky a poškození DNA u lidských pluripotentních kmenových buněk v souvislosti s nádorovou transformací. Další výzkum v této oblasti může mít obrovský dopad do praxe. Praktický význam lze také očekávat od výzkumu komplexních chromosomálních aberací. Účast informatiků v projektu umožní vývoj řídícího softwaru pro mikroskopickou techniku a velmi fundovanou analýzu získaných výsledků. Multidisciplinární povaha konsorcia projektu umožní využít komplementární metodiky a experimentální přístupy, dosáhnout synergických efektů, propojit prvky základního a aplikovaného výzkumu, řešit nejnáročnější úkoly. Společný výzkum tak bude mít vysokou přidanou hodnotu, která se projeví výrazným růstem excelence a mezinárodní úrovně zúčastněných pracovišť.
Title	Dynamics and Organization of Chromosomes in the Cell Cycle and during Differentiation under Normal and Pathological Conditions (en) Dynamika a organizace chromosomů během buněčného cyklu a při diferenciaci v normě a patologii
skos:notation	GBP302/12/G157
http://linked.open...avai/cep/aktivita	Projects for promotion of excellence in basic research
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/GBP302%2F12%2FG157/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/GBP302%2F12%2FG157/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2015-02-09 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	101113953
http://linked.open...ai/cep/hlavniObor	EA - Morfologické obory a cytologie
http://linked.open...vai/cep/kategorie	ZV - Základní výzkum
http://linked.open.../cep/klicovaSlova	chromosomes chromatin cell cycle differentiation ES cells DNA repair chromosomal aberrations (en)
http://linked.open...ep/partnetrHlavni	Biofyzikální ústav AV ČR, v.v.i.
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	3 (xsd:int)
http://linked.open.../pocetVysledkuRIV	97 (xsd:int)
http://linked.open...enychVysledkuVRIV	97 (xsd:int)
http://linked.open...lneniVMinulemRoce	2014-04-07 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/P302-12-G157
http://linked.open...iciPoslednihoRoku	2015
http://linked.open...atUdajeProjZameru	2015
http://linked.open.../vavai/cep/soutez	SGA02012GA-GB
http://linked.open...usZobrazovaneFaze	DRRVB
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2018-12-31 (xsd:date)
http://linked.open.../cep/vedlejsiObor	EB - Genetika a molekulární biologie FD - Onkologie a hematologie
http://linked.open...ep/zahajeniReseni	2012-01-01 (xsd:date)
http://linked.open...tniCyklusProjektu	ZBBB
is http://linked.open...vavai/riv/projekt of	Distinct chromatin organization in the germ line founder cell of the Caenorhabditis elegans embryo Driven hematopoietic differentiation of embryonic stem cells: Epigenetic perspectives Jumping-like translocation-a rare chromosomal rearrangement in a patient with Burkitt lymphoma/leukemia Mouse models of mantle cell lymphoma, complex changes in gene expression and phenotype of engrafted MCL cells: implications for preclinical research Morphologically Tunable Coassembly of Double Hydrophilic Block Polyelectrolyte with Oppositely Charged Fluorosurfactant Efficient k-NN based HEp-2 cells classifier Generation of Human Induced Pluripotent Stem Cells Using Genome Integrating or Non-integrating Methods Haematopoietic Developmental Potential of Human Pluripotent Stem Cell Lines Fusion of the additional sex combs like 1 and teashirt zinc finger homeobox 2 genes resulting from ider(20q) aberration in a patient with myelodysplastic syndrome Gold Nanoparticles for High Resolution Imaging in Modern Immunocytochemistry High density 3D localization microscopy using sparse support recovery From Endothelial Progenitor Cells to Tissue Engineering: How Far Have We Come? Hematopoietic differentiation of human pluripotent stem cells Generation of Human Induced Pluripotent Stem Cells Using Genome Integrating or Non-integrating Methods Function of chromatin structure and dynamics in DNA damage, repair and misrepair: gamma-rays and protons in action Frequent Chromatin Rearrangements in Myelodysplastic Syndromes - What Stands Behind? Trajectories and nuclear arrangement of PML bodies are influenced by A-type lamin deficiency Tumor-specific histone signature and DNA methylation in multiple myeloma and leukemia cells Adaptation to Robust Monolayer Expansion Produces Human Pluripotent Stem Cells With Improved Viability Curcumin-containing liposomes stabilized by thin layers of chitosan derivatives Decrease in Abundance of apurinic/apyrimidinic Endonuclease Causes Failure of Base Excision Repair in Culture-Adapted Human Embryonic Stem Cells CytoPacq v2.0 Deconvolution of huge 3-D images: Parallelization strategies on a multi-GPU system Epigenetic aspects of HP1 exchange kinetics in apoptotic chromatin Algorithms for Efficient Computation of Convolution Apoptosis in chronic myeloid leukemia cells transiently treated with imatinib or dasatinib is caused by residual BCR-ABL kinase inhibition. Synthesis of metallic nanoparticles by diatoms and chrysophytes - prospects and applications Involvement of deleted chromosome 5 in complex chromosomal aberrations in newly diagnosed myelodysplastic syndromes (MDS) is correlated with extremely adverse prognosis Interactions of serum with polyelectrolyte-stabilized liposomes: Cryo-TEM studies Intravenous insulin therapy during lung resection does not affect lung function or surfactant proteins Separation of replication and transcription domains in nucleoli RSurf - the Efficient Texture-Based Descriptor for Fluorescence Microscopy Images of HEp-2 Cells RSurf Texture Descriptor Tracking DNA and RNA Sequences at High Resolution ThunderSTORM: a comprehensive ImageJ plug-in for PALM and STORM data analysis and super-resolution imaging Three-Dimensional Reconstruction of the S885A Mutant of Human Mitochondrial Lon Protease Three-dimensional super-resolution structured illumination microscopy with maximum a posteriori probability image estimation miR-17-5p Regulates Endocytic Trafficking through Targeting TBC1D2/Armus Characterization of chromosome 11 breakpoints and the areas of deletion and amplification in patients with newly diagnosed acute myeloid leukemia Duration of the first steps of the human rRNA processing Differential effects of insulin and dexamethasone on pulmonary surfactant-associated genes and proteins in A549 and H441 cells and lung tissue DNA-damage response in chromatin of ribosomal genes and the surrounding genome Expression of human BRCA1 Delta 17-19 alternative splicing variant with a truncated BRCT domain in MCF-7 cells results in impaired assembly of DNA repair complexes and aberrant DNA damage response Hybrid detectors improved time-lapse confocal microscopy of PML and 53BP1 nuclear body co-localization in DNA lesions Apoptosis in Chronic Myeloid Leukemia Cells Transiently Treated with Imatinib or Dasatinib Is Caused by Residual BCR-ABL Kinase Inhibition Arrangement of nuclear structures is not transmitted through mitosis but is identical in sister cells Current optical sectioning systems in fluorescence microscopy Generation of Synthetic Image Datasets for Time-Lapse Fluorescence Microscopy GPU Optimization of Convolution for Large 3-D Real Images HEp-2 Cells Classifier Knockdown of apoptosis-inducing factor disrupts function of respiratory complex I Smooth Chan-Vese Segmentation via Graph Cuts Sequestration of MBNL1 in tissues of patients with myotonic dystrophy type 2 Towards a Realistic Distribution of Cells in Synthetically Generated 3D Cell Populations Structural Basis of Polycomb Bodies Statins in oncological research: From experimental studies to clinical practice Sub-Volume Averaging of Repetitive Structural Features in Angularly Filtered Electron Tomographic Reconstructions Flexible structured illumination microscope with a programmable illumination array Extension of Tamura Texture Features for 3D Fluorescence Microscopy Most Anti-BrdU Antibodies React with 2-Deoxy-5-Ethynyluridine — The Method for the Effective Suppression of This Cross-Reactivity Molecular Genetic Analysis of Fetal Tissues from a Family Affected by Myotonic Dystrophy Microscopic analysis of chromatin localization and dynamics in C. elegans Characterization of PEEK, PET and PI implanted with Mn ions and sub-sequently annealed Cell differentiation along multiple pathways accompanied by changes in histone acetylation status A simple Fourier filter for suppression of the missing wedge ray artefacts in single-axis electron tomographic reconstructions

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