About: Driven hematopoietic differentiation of embryonic stem cells: Epigenetic perspectives

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Hematopoietic progenitors derived from human embryonic stem cells (hESCs) present both a potential cell source for cell-replacement therapies and an in vitro model for hematopoietic stem cell (HSC) development. Current protocols for the hematopoietic differentiation of hESCs suffer from low efficiency and functional defects in the derived HSCs. Epigenetic mechanisms of HSC development should be addressed to overcome these imperfections. The focus of this review is to summarize the knowledge on the epigenetic regulation of pluripotency and lineage-specific genes with the emphasis on the hematopoietic cell lineage. The potential utilization of this knowledge to improve the generation of HSCs for clinical application is also discussed. Hematopoietic progenitors derived from human embryonic stem cells (hESCs) present both a potential cell source for cell-replacement therapies and an in vitro model for hematopoietic stem cell (HSC) development. Current protocols for the hematopoietic differentiation of hESCs suffer from low efficiency and functional defects in the derived HSCs. Epigenetic mechanisms of HSC development should be addressed to overcome these imperfections. The focus of this review is to summarize the knowledge on the epigenetic regulation of pluripotency and lineage-specific genes with the emphasis on the hematopoietic cell lineage. The potential utilization of this knowledge to improve the generation of HSCs for clinical application is also discussed. (en)
Title	Driven hematopoietic differentiation of embryonic stem cells: Epigenetic perspectives Driven hematopoietic differentiation of embryonic stem cells: Epigenetic perspectives (en)
skos:prefLabel	Driven hematopoietic differentiation of embryonic stem cells: Epigenetic perspectives Driven hematopoietic differentiation of embryonic stem cells: Epigenetic perspectives (en)
skos:notation	RIV/00216224:14330/14:00073400!RIV15-MSM-14330___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GBP302/12/G157), Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Stejskal, Stanislav Krontorád Koutná, Irena Tesařová, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	12384
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/14:00073400
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	epigenetic; stem cells; pluripotency; cell differentiation; hematopoietic development (en)
http://linked.open.../riv/klicoveSlovo	epigenetic hematopoietic development stem cells cell differentiation pluripotency
http://linked.open...odStatuVydavatele	AE - Stát Spojené arabské emiráty
http://linked.open...ontrolniKodProRIV	[2D5D8159D669]
http://linked.open...i/riv/nazevZdroje	CURRENT PHARMACEUTICAL DESIGN
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Dynamics and Organization of Chromosomes in the Cell Cycle and during Differentiation under Normal and Pathological Conditions
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	20
http://linked.open...iv/tvurceVysledku	Stejskal, Stanislav Krontorád Koutná, Irena Tesařová, Lenka
http://linked.open...ain/vavai/riv/wos	000334311500011
http://linked.open...n/vavai/riv/zamer	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	1381-6128
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.2174/13816128113199990524
http://localhost/t...ganizacniJednotka	14330

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