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| Description
| - Our intended project has been considered as a complex one, employing several progressive methodological approaches on various experimental systems as well as in humans. The study designed by us would cover all important areas, starting by an uptake ofxenobiotic, its biotransformation, formation of reactive, carcinogenic intermediates and their biological effects, the ability of the biological system to deal with a such damage as well as secondary processes associated with an exposure to adversechemical. The crutial role of DNA repair process in the cascade of genotoxic effects will be given proper attention. The acquired data may substantially contribute to our understanding complex processes resulting ultimately in chemical carcinogenesis. Wewould also like, on the base of our results, to address a point of individual risk. (en)
- Námi navrhovaný projekt je pojat jako komplexní studie, využívající progresivní metodologické přístupy v řadě experimentálních systémů i v lidské populační studii. V naší studii bychom rádi pokryli nejdůležitější oblasti působení styrenu, počínajevstupem xenobiotika do organismu, jeho biotransformaci, tvorbou reaktivních, karcinogenních meziproduktů a jejich biologickými účinky, schopností biologického systému se s těmito poškozeními vypořádat, jakož i druhotné procesy spjaté s expozici škodlivýmchemickým látkám. Pozornost věnujeme nesmírně významné úloze DNA reparačních procesů v kaskádě genotoxických účinků. Výsledky získané v průběhu naší studie by mohly významně přispět k pochopení komplexních pochodů, které mohou v konečném důsledku vést kekarcinogenicitě. Našimi výsledky bychom rádi přispěli do diskuse k individuálnímu riziku v chemické karcinogeneze.
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| Title
| - New aspects in understanding styrene genotoxicity: the role of DNA repair,new reactive metabolites and secondary oxidative stress (en)
- Aktuální otázky v chápání genotoxicity styrenu: úloha DNA reparací, nových reaktivních metabolitů a sekundárního oxidativního stresu
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...okUkonceniPodpory
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| http://linked.open...okZahajeniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...jektu+dodavatelem
| - In the present project we have addressed mechanisms of genotoxic effects of potentially carcinogenic chemical, styrene. Our approach has been quite a complex one, comprising studies in vitro, on experimental animals as well as on both exposed and control (en)
- V tomto projektu jsme se soustředili na studium genotoxických účinků potenciálně karcinogenní látky, styrenu. Zvolili jsme komplexní přístup k této problematice, zahrnující studie in vitro, experimenty na zvířeti, jakož i stude na populaci exponované sty (cs)
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| http://linked.open...tniCyklusProjektu
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| is http://linked.open...vavai/riv/projekt
of | - Cytogenetic Markers, DNA Single-Strand Breaks, Urinary Metabolites, and DNA Repair Rates in Styrene-Exposed Lamination Workers
- Genetic polymorphisms in DNA repair genes and possible links with DNA repair rates, chromosomal aberrations and single-strand breaks in DNA
- Markers of individual susceptibility and DNA repair rate in workers exposed to xenobiotics in a tire plant
- Syntheses of O6-Alkyl- and Arylguanine Derivatives, Nucleobase Adducts Derived from Styrene 7,8- and 3,4-oxides.
- 7-Alkylguanine adduct levels in urine, lungs and liver of mice exposed to styrene by inhalation
- Styrene metabolism, genotoxicity, an potential carcinogenicity
- Genetic polymorphisms and possible gene-gene interactions in metabolic and DNA repair genes: Effect on DNA damage
- Syntheses of 7-(2-hydroxy-1-phenylethyl)- and 7-(2-hydroxy-2-phenylethyl)guanine, DNA adducts derived from styrene 7,8-oxide
- DNA repair and cyclin D1 polymorphisms and styrene-induced genotoxicity and immunotoxicity
- Phenyl(hydroxyethyl)guanines
- Hydroxy(phenyl)ethyl derivatives of adenine and guanine as biomarkers of exposure to styrene, their synthesis and analysis in the urine
- The repair of DNA damage induced in human peripheral lymphocytes with styrene oxide
- The role of various biomarkers in the evaluation of styrene genotoxicity
- N7-ALKYLGUANINES IN THE URINE OF MICE EXPOSED TO STYRENE
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| is http://linked.open...vavai/cep/projekt
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