About: Syntheses of 7-(2-hydroxy-1-phenylethyl)- and 7-(2-hydroxy-2-phenylethyl)guanine, DNA adducts derived from styrene 7,8-oxide

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About: Syntheses of 7-(2-hydroxy-1-phenylethyl)- and 7-(2-hydroxy-2-phenylethyl)guanine, DNA adducts derived from styrene 7,8-oxide Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Syntheses of 7-(2-hydroxy-1-phenylethyl)- and 7-(2-hydroxy-2-phenylethyl)guanine, DNA adducts derived from styrene 7,8-oxide (cs) 7-Hydroxy(phenyl)ethylguanines are important DNA adducts which can be used as markers of exposure to styrene. Two synthetic routes leading to these compounds are presented using allyl protected bromohydrins as synthetic equivalents of styrene 7,8-oxide to alkylate 2-amino-6-chloropurine or 7-methyl-10-oxo-9,10-dihydropyrimido[1,2-a]purine as precursors to guanine 7-Hydroxy(phenyl)ethylguanines are important DNA adducts which can be used as markers of exposure to styrene. Two synthetic routes leading to these compounds are presented using allyl protected bromohydrins as synthetic equivalents of styrene 7,8-oxide to alkylate 2-amino-6-chloropurine or 7-methyl-10-oxo-9,10-dihydropyrimido[1,2-a]purine as precursors to guanine (en)
Title	Syntheses of 7-(2-hydroxy-1-phenylethyl)- and 7-(2-hydroxy-2-phenylethyl)guanine, DNA adducts derived from styrene 7,8-oxide Syntheses of 7-(2-hydroxy-1-phenylethyl)- and 7-(2-hydroxy-2-phenylethyl)guanine, DNA adducts derived from styrene 7,8-oxide (en) Syntheses of 7-(2-hydroxy-1-phenylethyl)- and 7-(2-hydroxy-2-phenylethyl)guanine, DNA adducts derived from styrene 7,8-oxide (cs)
skos:prefLabel	Syntheses of 7-(2-hydroxy-1-phenylethyl)- and 7-(2-hydroxy-2-phenylethyl)guanine, DNA adducts derived from styrene 7,8-oxide Syntheses of 7-(2-hydroxy-1-phenylethyl)- and 7-(2-hydroxy-2-phenylethyl)guanine, DNA adducts derived from styrene 7,8-oxide (en) Syntheses of 7-(2-hydroxy-1-phenylethyl)- and 7-(2-hydroxy-2-phenylethyl)guanine, DNA adducts derived from styrene 7,8-oxide (cs)
skos:notation	RIV/60461373:22310/04:00012335!RIV/2005/GA0/223105/N
http://linked.open.../vavai/riv/strany	2738-2746
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA310/03/0437)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Linhart, Igor Novák, Jan Dvořáková, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemické technologie
http://linked.open...dnocenehoVysledku	589309
http://linked.open...ai/riv/idVysledku	RIV/60461373:22310/04:00012335
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	protecting groups;guanines (en)
http://linked.open.../riv/klicoveSlovo	protecting groups guanines
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[B02F28AB7CED]
http://linked.open...i/riv/nazevZdroje	European Journal of Organic Chemistry
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	New aspects in understanding styrene genotoxicity: the role of DNA repair,new reactive metabolites and secondary oxidative stress
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	Neuveden
http://linked.open...iv/tvurceVysledku	Novák, Jan Dvořáková, Hana Linhart, Igor
issn	1434-193X
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	22310

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