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Description
| - Phenyl(hydroxy)ethylguanines, in particular 7-(2-hydroxy-1-phenylethyl)guanine and 7-(2-hydroxy-2-phenylethyl)guanine, are important markers of exposure to styrene as well as indicators of DNA damage caused by styrene 7,8-oxide, a styrene metabolite. An improved synthetic procedure leading to these compounds has been developed. As a rule, the alkylation reactions of guanine and guanine derivatives are rather unselective. The selectivity of alkylation was improved by using 7-methyl-10-oxo-9,10-dihydropyrimido[1,2-a]purine as a protected guanine compound, and allyl-protected bromohydrins as synthetic equivalents of styrene 7,8-oxide.
- Phenyl(hydroxy)ethylguanines, in particular 7-(2-hydroxy-1-phenylethyl)guanine and 7-(2-hydroxy-2-phenylethyl)guanine, are important markers of exposure to styrene as well as indicators of DNA damage caused by styrene 7,8-oxide, a styrene metabolite. An improved synthetic procedure leading to these compounds has been developed. As a rule, the alkylation reactions of guanine and guanine derivatives are rather unselective. The selectivity of alkylation was improved by using 7-methyl-10-oxo-9,10-dihydropyrimido[1,2-a]purine as a protected guanine compound, and allyl-protected bromohydrins as synthetic equivalents of styrene 7,8-oxide. (en)
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Title
| - Phenyl(hydroxyethyl)guanines
- Phenyl(hydroxyethyl)guanines (en)
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skos:prefLabel
| - Phenyl(hydroxyethyl)guanines
- Phenyl(hydroxyethyl)guanines (en)
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skos:notation
| - RIV/60461373:22640/03:00008200!RIV/2004/GA0/226404/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60461373:22640/03:00008200
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Pyrimidopurines; diagnisis of DNA damage (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...v/mistoKonaniAkce
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http://linked.open...i/riv/mistoVydani
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http://linked.open...i/riv/nazevZdroje
| - 10th Blue Danube Symposium on Heterocyclic Chemistry
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...ocetUcastnikuAkce
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http://linked.open...nichUcastnikuAkce
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Novák, Jan
- Dvořáková, Hana
- Linhart, Igor
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http://linked.open...vavai/riv/typAkce
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http://linked.open.../riv/zahajeniAkce
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number of pages
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http://purl.org/ne...btex#hasPublisher
| - 10th Blue Danube Symposium on Heterocyclic Chemistry
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https://schema.org/isbn
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http://localhost/t...ganizacniJednotka
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