About: Phenyl(hydroxyethyl)guanines     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
Description
  • Phenyl(hydroxy)ethylguanines, in particular 7-(2-hydroxy-1-phenylethyl)guanine and 7-(2-hydroxy-2-phenylethyl)guanine, are important markers of exposure to styrene as well as indicators of DNA damage caused by styrene 7,8-oxide, a styrene metabolite. An improved synthetic procedure leading to these compounds has been developed. As a rule, the alkylation reactions of guanine and guanine derivatives are rather unselective. The selectivity of alkylation was improved by using 7-methyl-10-oxo-9,10-dihydropyrimido[1,2-a]purine as a protected guanine compound, and allyl-protected bromohydrins as synthetic equivalents of styrene 7,8-oxide.
  • Phenyl(hydroxy)ethylguanines, in particular 7-(2-hydroxy-1-phenylethyl)guanine and 7-(2-hydroxy-2-phenylethyl)guanine, are important markers of exposure to styrene as well as indicators of DNA damage caused by styrene 7,8-oxide, a styrene metabolite. An improved synthetic procedure leading to these compounds has been developed. As a rule, the alkylation reactions of guanine and guanine derivatives are rather unselective. The selectivity of alkylation was improved by using 7-methyl-10-oxo-9,10-dihydropyrimido[1,2-a]purine as a protected guanine compound, and allyl-protected bromohydrins as synthetic equivalents of styrene 7,8-oxide. (en)
Title
  • Phenyl(hydroxyethyl)guanines
  • Phenyl(hydroxyethyl)guanines (en)
skos:prefLabel
  • Phenyl(hydroxyethyl)guanines
  • Phenyl(hydroxyethyl)guanines (en)
skos:notation
  • RIV/60461373:22640/03:00008200!RIV/2004/GA0/226404/N
http://linked.open.../vavai/riv/strany
  • PO-115
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA310/03/0437)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 620787
http://linked.open...ai/riv/idVysledku
  • RIV/60461373:22640/03:00008200
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Pyrimidopurines; diagnisis of DNA damage (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [A7F21434AAB4]
http://linked.open...v/mistoKonaniAkce
  • Vídeň, Rakousko
http://linked.open...i/riv/mistoVydani
  • Bratislava
http://linked.open...i/riv/nazevZdroje
  • 10th Blue Danube Symposium on Heterocyclic Chemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...ocetUcastnikuAkce
http://linked.open...nichUcastnikuAkce
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Novák, Jan
  • Dvořáková, Hana
  • Linhart, Igor
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
number of pages
http://purl.org/ne...btex#hasPublisher
  • 10th Blue Danube Symposium on Heterocyclic Chemistry
https://schema.org/isbn
  • 80-227-1938-2
http://localhost/t...ganizacniJednotka
  • 22640
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software